复杂型小儿高热惊厥转化为癫痫的影响因素分析

目的探讨复杂型小儿高热惊厥转变为癫痫的影响因素.方法对162例复杂型高热惊厥患儿的临床资料,进行调查及回顾性分析.结果162例患儿发展为癫痫的共32例(19.75%),其中有癫痫家族史的35例,转化为癫痫的15例(42.86%);有影响神经系统发育因素的55例,转化为癫痫20例(36.36%);发热距惊厥发作的时间越短转化为癫痫的比例越高.结论有癫痫家族史及有影响神经系统发育因素的、发热与出现惊厥的间隔时间均为复杂型高热惊厥发展成癫痫的重要因素.

Factor analysis of complex febrile seizures of childhood developing to epilepsy

Objective To investigate the risk factors which affect complex febrile seizures developing into epilepsy. Methods Retrospective analysis of 162 complex febrile seizure cases was carried out. Results Fifteen out of 35 children who had familial history of epilepsy developed into epilepsy. Twenty out of 55 cases who had neurological abnormalities developed into epilepsy. Nineteen out of 37 cases of who the length between fever and febrile seizure was less than 1 h developed into epilepsy, but only 13 in 125 patients developed into epilepsy when the interval between fever and seizure was more than 1 h. Conclusion The predictive risk factors for complex febrile seizures developing into epilepsies are familial history of epilepsy, abnormal neurological development, and short intervals between fever and febrile seizure activities.