腹膜透析、血液透析对维持性透析患者事件相关电位P300的影响

目的对比腹膜透析(简称腹透)、血液透析(简称血透)对维持性透析患者事件相关电位P300(简称P300)的影响。方法选择72例须行维持性透析的终末期肾衰竭(ESRD)患者,腹透组30例,血透组42例,分别测定两组治疗开始前及治疗后1年P300的潜伏期、波幅。结果治疗前腹透组和血透组P300潜伏期和波幅分别为(397.6±35.9)ms,(8.3±1.57)μV和(405.3±46.7)ms,(7.9±1.43)μV],差异无统计学意义(P>0.05),治疗1年后腹透组和血透组P300潜伏期和波幅分别为(320.6±31.95)ms,(10.8±1.06)μV和(345.6±33.28)ms,(9.5±1.12)μV],差异有统计学意义(P<0.01)。结论不同透析方式对维持性透析患者P300的影响程度不同,腹透对改善长期维持性透析患者的认知功能可能较血透好。

Effects of peritoneum dialysis and hemodialysis on event-related potentials P300 in patients with receiving maintenance dialysis

Objective To observe the effect of peritoneum dialysis and hemodialysis on event-related potentials P300 in patients with receiving maintenance dialysis.Methods Seven-two end-stage renal disease(ESRD) patients with receiving maintenance dialysis were randomly divided into two groups:a peritoneum dialysis group(n=30),and a hemodialysis group(n=42).P300 latencies and amplitudes were detected before and after treatment for 1 year.Results Before treatment,there were no significant differences in P300 latencies and amplitudes between the peritoneum dialysis group (397.6±35.9) ms,(8.3±1.57)μV]and the hemodialysis group(405.3±46.7)ms,(7.9±1.43)μV].After 1 year of treatment,P300 latencies reduced and amplitudes increased in two groups,however,in peritoneum dialysis group P300 latencies reduced and amplitudes increased significantly(P<0.01).Conclusion Both peritoneum dialysis and hemodialysis can improve the cognitive function in patients with receiving maintenance dialysis,the effect of peritoneum dialysis was better than that of hemodialysis.