肺癌组织中Cox-2蛋白表达及对预后影响的研究

目的:探讨Cox-2蛋白在肺癌组织中的表达水平及其对预后的影响。方法:应用免疫组化方法检测116例肺癌组织中Cox-2蛋白表达水平,并用CD34标记血管计数肿瘤组织中微血管密度。结果:116例肺癌组织中,Cox-2蛋白阳性78例(67.2%)。Cox-2蛋白的表达与肿瘤TNM分期(P=0.014)及其淋巴结转移情况(P=0.009)密切相关,且阳性表达的肺癌组织中微血管密度明显高于阴性表达者,P=0.000。COX模型多因素分析显示,淋巴结的转移(P=0.004)和Cox-2蛋白的阳性表达(P=0.000)是肺癌患者的预后不良因素。结论:Cox-2蛋白阳性表达可作为判断肺癌患者预后不良的潜在指标。

Prognostic significance of the expression of Cox-2 in lung cancer

OBJECTIVE:To investigate the prognostic significance of the expression of Cox-2 protein in lung cancer.METHODS:The positive expressions of Cox-2 and CD34 proteins were observed in 116 cases of lung cancer by immunohistochemical staining and the microvascular density of tumor was counted.RESULTS:The positive rate of Cox-2 protein expression in the specimens of 116 lung cancer was 67.2%(78 cases).The expression of Cox-2 was related to tumor TNM staging(P=0.014)and lymph nodes metastasis(P=0.009),and the microvascular density in the positive expression of lung cancer was significantly higher than that in the negative expression,P=0.000.COX model showed that lymph nodes metastasis(P=0.004)and the positive expression of Cox-2 protein(P=0.000)were poor factors to the prognosis of lung cancer patients.CONCLUSION:Protein Cox-2 can be served as a potential marker of prognosis in lung cancer.