| 尖锐湿疣及疣旁组织中p53及bcl—2的表达 |
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| 引用本文： | 罗迪青,陈志和,翁智胜. 尖锐湿疣及疣旁组织中p53及bcl—2的表达[J]. 中国优生与遗传杂志, 2001, 9(3): 19-19,21 |
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| 作者姓名： | 罗迪青 陈志和 翁智胜 |
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| 作者单位： | 1. 广州市第二人民医院内科,
2. 广州市第二人民医院皮肤科, |
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| 摘 要： | 目的研究癌相关基因bcl-2和p53在尖锐湿疣(CA)及疣旁组织中的表达,探讨他们与尖锐湿疣中细胞增生的关系.方法用免疫组织化学LSAB法对31例CA组织及15例疣旁组织进行了检测.结果所有阳性表达细胞均位于基底层.湿疣及疣旁组织中均有表达,p53表达率分别是66.7%(21/31)和26.7%(4/15)(P＜0.025).而bcl-2表达率分别是41.9%(13/31)和6.7%(1/15)(P＜0.05).结论提示bcl-2和p53两种癌相关基因的异常表达与CA发病机制有一定关系.
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| 关 键 词： | 尖锐湿疣 疣旁组织 癌基因 p53／bcl－2 免疫组织化学 |
A contrast study: expression of both bcl- 2 and p53 oncoprotein in condylona acuminatun and beside-wart tissue |
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| Luo Diqing,Chen Zhihe,Weng Zhisheng.. A contrast study: expression of both bcl- 2 and p53 oncoprotein in condylona acuminatun and beside-wart tissue[J]. Chinese Journal of Birth Health & Heredity, 2001, 9(3): 19-19,21 |
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| Authors: | Luo Diqing Chen Zhihe Weng Zhisheng. |
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| Abstract: | Objective:The purpose of this study is to detect both bcl-2 and p53 in bothcondyloma acuminatum(CA) and beside-wart tissue,then ascertain the correlation between them and the pathogenic mechanism of epidermic hyperplasia in CA.Method:p53 and bcl-2 proteins were detected by immunohistochemical LSAB method on paraffin-embedded sections from 31 CA specimens and 15 beside-wart tissues.Results:In all cases,most of th positive cells were in the basal layer.p53 protein was found in nucleus.67.7%(21/31)of CA cases and 26.7%(4/15) of beside-wart tissues were positive.Bcl-2 protein was located in cytoplasm.41.9(13/31) of CA and 6.7%(1/15)of beside-wart tissues were positive.Between CA and beside-wart tissues,there were significant difference in both p53 and bcl-2 respectively(P>0.025 and P<0.05 respectively).Conclusion:The results suggested that bcl-2 and p53 be two important factors in the pathogenic mechanism of CA,especially the epidermic hyperplasia. |
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| Keywords: | Condyloma acuminatum Beside-wart tissue Oncogene p53/Bcl-2 Immunohistochemistry |
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