Intracytoplasmic sperm injection in obstructive and non-obstructive azoospermia |
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Authors: | Mansour RT; Kamal A; Fahmy I; Tawab N; Serour GI; Aboulghar MA |
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Institution: | The Egyptian IVF-ET Center, Maadi, Cairo, Egypt. |
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Abstract: | We compared the results of intracytoplasmic sperm injection (ICSI) in: (i)
obstructive versus non-obstructive azoospermia, (ii) obstructive
azoospermia using epididymal versus testicular spermatozoa and (iii)
acquired versus congenital obstructive azoospermia due to congenital
absence of the vas deferens (CAVD). A retrospective analysis was done of
241 consecutive ICSI cycles done in 103 patients with non- obstructive
azoospermia and 119 patients with obstructive azoospermia. In the
obstructive group, 135 ICSI cycles were performed. Epididymal spermatozoa
were used in 44 cycles and testicular spermatozoa in 91 cycles. In the
non-obstructive group, 106 cycles were performed. The fertilization and
pregnancy per cycle rates were 59.5 and 27.3% respectively using epididymal
spermatozoa, 54.4 and 31.9% respectively using testicular spermatozoa in
obstructive cases, and 39 and 11.3% respectively in non-obstructive cases.
The fertilization and pregnancy per cycle rates were 56.6 and 37%
respectively in acquired obstructive cases, and 55.2 and 20.4% respectively
in CAVD. In conclusion, ICSI using spermatozoa from patients with acquired
obstructive azoospermia resulted in significantly higher fertilization and
pregnancy rates as compared to CAVD and non-obstructive cases.
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