盐酸米诺环素软膏对微螺钉支抗种植体周围炎龈下牙龈卟啉单胞菌影响

目的:探讨盐酸米诺环素软膏对微螺钉支抗种植体周围炎龈下牙龈卟啉单胞菌(Porphyromonas gingivalis,Pg)影响。方法:选取我院2013年1月~2015年1月收治的15例微螺钉支抗治疗后种植体周围炎的患者,共20种植体,为观察组;选取同期于我院接受微螺钉支抗治疗的患者14例,共20种植体,经证实无种植体周围炎,为对照组。记录两组菌斑指数(PLI)、牙周袋探诊指数(PD)及龈沟出血指数(SBI )。采用实时荧光定量PCR检测Pg。结果:治疗前与治疗后,观察组PLI、PD和SBI均显著高于对照组(P<0.01或P<0.05),治疗1、3周后观察组PLI、PD和SBI显著降低,治疗6周后有上升趋势,但与治疗前相比差异仍有统计学意义(P<0.05);治疗前与治疗后6周,观察组Pg检出率显著高于对照组(P<0.05),治疗1、3周后观察组Pg检出率显著降低并与对照组接近,治疗6周后有上升趋势;Pg检出率与临床指标PLI、PD和SBI成正相关性(P<0.05)。结论:盐酸米诺环素软膏治疗微螺钉支抗种植体周围炎,可明显改善种植体周围炎临床症状,其对Pg具有较强的抗菌效果。

Effect of Minocycline Hydrochloride Ointment on Subgingival Porphyromonas Gingivalis of Peri-microscrew Implantitis.

Objective: To investigate the effect of minocycline hydrochloride ointment on subgingival porphyromonas gingivalis of peri-microscrew implantitis. Methods: Fifteen patients (20 microscrews) with peri-microscrew implantitis from Jan 2013 to Jan 2015 were set as experimetal group and 14 patients (20 microscrews) without peri-microscrew implantitis were set as control group. Plaque index (PLI), probing pocket index (PD) and sulcus bleeding index (SBI) of all patitents were recorded. Real-time PCR was used to detect the Porphyromonas gingivalis. Results: The values of PLI, PD and SBI in experimental group were significantly higher than those in the control group (P<0.05). After treatment for 1 and 3 weeks, the values of PLI, PD and SBI in experimental group were significantly decreased (P<0.05). Before and after treatment for 6 weeks, the Pg relevance ratio in experimental group was significantly higher than that in control group (P<0.05). After treatment for 1 and 3 weeks, the relevance ratio in experimental group significantly decreased. There was significant positive Pearson correlation between the detection rate of Pg and the PLI, PD and SBI (P<0.05). Conclusion: Minocycline hydrochloride ointment treatment could improve clinical symptom and had inhibitory effect on subgingival porphyromonas gingivalis of peri-microscrew implantitis