难治性牙周炎患者血清中瘦素(LEP)水平及其与牙周临床指数关系分析

目的: 探讨难治性牙周炎患者的血清瘦素水平以及其与牙周临床指数之间的关系。方法: 本文随机选取健康组、慢性牙周炎组以及难治性牙周炎组患者各40例,记录所有接受检测者的牙周炎临床指标牙周袋探诊深度(PD)、菌斑指数(PLI)、牙周附着水平(AL)以及探诊出血(BOP)的相关变化情况;然后采用高效液相关层析法检测所有接受检查患者的糖化血红蛋白(HBALC)以及空腹血糖(FPG)指标变化情况,并且同时使用酶联免疫吸附法(ELISA)检测患者血清中瘦素(LEP)表达水平变化情况。结果: 难治性牙周炎组中患者的血清中HBALC(10.902±2.129)%、FPG(9.783±2.109) mmoL/L、LEP(1.347±0.658) μg/L的浓度明显高于慢性牙周炎组和健康组HBALC(5.601±0.375)%、(5.142±0.319)%、FPG(5.689±0.712)、(5.432±0.467) mmoL/L、LEP(0.912±0.256)、(0.462±0.119) ng/mL(P<0.05);所有受试者的血清瘦素指标与PD、AL、PLI以及BOP指标值都呈正相关,R值依次分别为0.497、0.534、0.509和0.571(P<0.05)。结论: 难治性牙周炎患者血清中瘦素水平会逐渐升高,血清瘦素水平与PD、AL、PLI以及BOP指标呈正相关的关系。

Correlation Analysis between Serum Leptin and Periodontal Indexes of Patients with Refractory Periodontitis.

Objective: To investigate the relationship between serum leptin and periodontal indices of patients with refractory periodontitis. Methods: The study comprised of total 120 subjects (healthy controls=40, chronic periodontitis patients=40, and refractory periodontitis patients=40). The indices were detected including periodontal pocket probing depth (PD), plaque index (PLI), periodontal attachment level (AL) and the related changes in bleeding on probing (BOP). The expression levels of glycated hemoglobin (HBALC) and fasting plasma glucose (FPG) were examined by liquid chromatography. The serum leptin (LEP) expression level was determined by an enzyme-linked immunosorbent assay (ELISA). Results: The expression levels of HBALC (10.902±2.129)%, FPG (9.783±2.109) mmol/L, and LEP (1.347±0.658) μg/L in refractory periodontitis group were significantly higher than those of the chronic periodontitis group and healthy controls (HBALC (5.601±0.375), (5.142±0.319)%, FPG (5.689±0.712), (5.432±0.467) mmol/L, LEP (0.912±0.256), (0.462±0.119) μg/L (P<0.05)). There was a positive correlation between the expression level of serum leptin and the clinical periodontal indices including PD, AL, PLI and BOP (R values were 0.497, 0.534, 0.509 and 0.571 (P<0.05)). Conclusion: Expression levels of serum leptin is upregulated in patients with refractory periodontitis, which is positively correlated with PD, AL, PLI and BOP, respectively.