| 抑郁症组学生物标志物的研究进展 |
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| 引用本文： | 朱立静,孙冰婷,宗阳,何书芬,居文政,谈恒山.抑郁症组学生物标志物的研究进展[J].中国医院药学杂志,2016,36(23):2131-2134. |
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| 作者姓名： | 朱立静 孙冰婷 宗阳 何书芬 居文政 谈恒山 |
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| 作者单位： | 1. 南京中医药大学附属医院, 江苏 南京 210029;
2. 南京军区总医院, 江苏 南京 210002 |
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| 基金项目： | 国家自然科学基金资助项目（编号：81573685）；重大新药创制（编号：2012ZX09303009-002） |
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| 摘 要： | 抑郁症是一种严重的精神疾病，患病率约为15%，极大地影响了患者生活质量。然而抑郁症的发病机制尚未明确，缺乏客观的诊断方法，生物标志物可以为抑郁症的诊断及治疗提供一定的科学依据，目前公认的经典生物标志物主要包括单胺类神经递质、下丘脑-垂体-肾上腺轴因素、细胞因子、脑神经营养因子等，但存在一定的缺陷，本文主要对抑郁症组学生物标志物的研究进展进行了综述，包括基因组学，蛋白质组学，代谢组学。
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| 关 键 词： | 抑郁症 组学生物标志物 生物标志物 |
| 收稿时间： | 2016-04-06 |
Research progress on omics biomarkers of depression |
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| ZHU Li-jing,SUN Bing-ting,ZONG Yang,HE Shu-fen,JU Wen-zheng,TAN Heng-shan.Research progress on omics biomarkers of depression[J].Chinese Journal of Hospital Pharmacy,2016,36(23):2131-2134. |
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| Authors: | ZHU Li-jing SUN Bing-ting ZONG Yang HE Shu-fen JU Wen-zheng TAN Heng-shan |
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| Institution: | 1. Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Nanjing 210029, China;
2. Nanjing General Hospital of Nanjing Military Command, Jiangsu Nanjing 21002, China |
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| Abstract: | Depression is a serious mental illness,and the prevalence is about 15%, which greatly affects the quality of patients' life. However, its pathogenesis is not yet clear,and diagnosis is lack of objective check, and biomarker can provide a certain scientific basis for the diagnosis and treatment of depression. Currently, recognized classical biomarker mainly includes the monoamine neurotransmitters, factors of the hypothalamic pituitary adrenal axis, cell factor, brain-derived neurotrophic factor and so on.This paper introduces the research progress of omics biomarkers of depression, including genomics, proteomics, metabonomics. |
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| Keywords: | depression omics biomarkers biomarkers |
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