单中心214例非肌层浸润性膀胱癌复发因素分析

Exploring the risk factors of recurrence in 214 patients with non-muscle invasive bladder cancer by retrospectively analysis

Objective:To explore the main influencing factors and clinical significance of the recurrence of non-muscle invasive bladder cancer (NMIBC). Methods: Two hundred and fourteen patients with NMIBC were retrospectively reviewed in single center. Gender, age，BMI ,hypert-ension,diabetes,tumor size, tumor number, tumor grade, tumor stage, immediately intravesical instillation and intravesical chemotherapy were predicted to be the risk factors.Survival analysis was carried out by employing Kaplan-Meier and Cox proportional hazard model. Results: Finally 214 patients with NMIBC were studied, with mean age of 68.5 years at presentation, and male to female ratio was 1.4∶1. Based on 8-48 months of following up, 63(29.3%) of 214 cases had recurrence .Univariate analysis indicated that number, size, grade and stage of tumor and immediate intravesical instillation were significantly associated with the recurrence of NMIBC (all P<0.05). Number, size, grade and stage of tumor and immediate intravesical instillation were independent risk factors for recurrence of NMIBC. Conclusion: number, size, grade and stage of tumor are the independent risk factors for recurrence of NMIBC. Immediate intravesical instillation is protective for recurrence of NMIBC.