| 乳腺癌干细胞的调控及作用 |
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| 引用本文： | 吴海歌,高晨慧,刘雨晴,姚子昂. 乳腺癌干细胞的调控及作用[J]. 肿瘤防治研究, 2016, 43(9): 801-805. DOI: 10.3971/j.issn.1000-8578.2016.09.015 |
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| 作者姓名： | 吴海歌 高晨慧 刘雨晴 姚子昂 |
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| 作者单位： | 116622 大连，大连大学生命科学与技术学院 辽宁省糖脂代谢研究重点实验室 |
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| 基金项目： | 国家自然科学基金（81373429）；青年科学基金（30901875）；辽宁省优秀人才支持计划 |
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| 摘 要： | 乳腺癌是威胁妇女健康的重要疾病之一，由于其病因尚不完全清楚，目前还没有确切的预防方法，手术和放化疗是其主要的治疗办法，但其风险大且具有一定不良反应。研究发现，从实体肿瘤中分离出来的具有自我更新和多向分化能力的乳腺癌干细胞，能够介导肿瘤的侵入、转移和复发等过程，并且能够抵抗传统的放化疗，这对研究以乳腺癌干细胞为靶点的治疗方法具有重要的理论价值和实践意义。本文对乳腺癌干细胞的调控及作用的最新进展作一综述。
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| 关 键 词： | 乳腺癌 乳腺癌干细胞 调控 治疗 |
| 收稿时间： | 2015-12-02 |
Regulations and Roles of Breast Cancer Stem Cells |
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| WU Haige,GAO Chenhui,LIU Yuqing,YAO Ziang. Regulations and Roles of Breast Cancer Stem Cells[J]. Cancer Research on Prevention and Treatment, 2016, 43(9): 801-805. DOI: 10.3971/j.issn.1000-8578.2016.09.015 |
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| Authors: | WU Haige GAO Chenhui LIU Yuqing YAO Ziang |
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| Affiliation: | College of Life Science and Technology, Dalian University, Key Laboratory of Glycolipid Metabolism of Liaoning Province, Dalian 116622, China |
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| Abstract: | Breast cancer is one kind of serious diseases threatening the health of women, and there is no exact prevention method due to its unclear mechanisms. Surgery, radiotherapy and chemotherapy are the main treatment methods, unpleasantly, following with side effects and high risk. Researches show that the breast cancer stem cell(BCSC) isolated from the solid tumors, owning the ability of self-renewal and multi-directional differentiation, can mediate tumor invasion, metastasis, relapse and resist conventional radiochemotherapy, which makes an important theoretical and practical contribution on breast cancer treatment targeting on stem cells. Here in, we summarize the recent progress on the regulations and roles of breast cancer stem cells. |
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| Keywords: | Breast cancer Breast cancer stem cells Regulation Treatment |
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