西帕依固龈液联合双黄连颗粒外用治疗复发性口腔溃疡疗效分析

目的 观察西帕依固龈液联合双黄连颗粒外用治疗复发性口腔溃疡的临床效果。 方法 将2014年1月—2015年12月间丽水市人民医院就诊的166例复发性口腔溃疡患者采用随机数字法分为2组，每组患者83例。对照组给予西帕依固龈液含漱治疗，观察组在此基础上加用双黄连颗粒涂于溃疡面。2组均治疗5 d。治疗前后，检测患者血清中肿瘤坏死因子α(TNF-α)、白细胞介素-2(IL-2)和白细胞介素-6(IL-6)水平。并统计2组溃疡面情况、疼痛程度和治疗效果。采用SPSS 20.0统计学软件对收集的2组数据进行统计学分析，进而对西帕依固龈液联合双黄连颗粒外用治疗复发性口腔溃疡的临床效果进行分析。 结果 2组治疗后TNF-α、IL-6水平显著降低(P＜0.05)，且观察组患者TNF-α、IL-6水平显著低于对照组(P＜0.05)；2组治疗后IL-2水平显著升高(P＜0.05)，且观察组患者IL-2水平显著高于对照组(P＜0.05)。治疗后，2组溃疡直径、溃疡疼痛均显著降低(P＜0.05)，观察组溃疡直径、溃疡疼痛均显著低于对照组(P＜0.05)。观察组总有效率为86.5％，明显高于对照组的75.6％(P＜0.05)。 结论 西帕依固龈液联合双黄连颗粒外用可有效降低复发性口腔溃疡患者的炎性反应，促进溃疡面愈合，减少疼痛，治疗效果满意，值得推广。 

Efficacy of Xipayi collutory combined with Shuanghuanglian granules in treatment of recurrent oral ulcer

Objective To investigate the clinical efficacy of Xipayi collutory combined with Shuanghuanglian granules in the treatment of recurrent oral ulcer. Methods Total 166 cases of recurrent oral ulcer in our hospital between January,2014 and December,2015 were enrolled and randomly divided into 2 groups with 83 cases in each group.The patients in the control group were given Xipayi collutory,while the patients in the observation group were given additional Shuanghuanglian granules on the basis of Xipayi collutory.The patients in the two groups were treated for 5 days.Before and after the treatment,serum tumor necrosis factor-α(TNF-α),interleukin-2(IL-2) and interleukin-6(IL-6) levels of both groups were detected.The ulcer status and pain degree of the two groups were accounted.SPSS statistical software was used to analyze the difference in the therapeutic efficacy between the two groups. Results After the treatment,TNF-α and IL-6 levels of both groups were significantly reduced(P<0.05),and TNF-α and IL-6 levels of the observation group was significantly lower than that of the control group(P<0.05).After the treatment,IL-2 levels of the two groups were significantly elevated(P<0.05),and IL-2 level of the observation group was significantly higher than that of the control group(P<0.05).The ulcer diameter and pain degree of the observation group was significantly lower than those in the control group(P<0.05).The total efficacy rate of the observation group was 89.5%,which was significantly higher than the control group(75.6%),P<0.05. Conclusion Xipayi collutory combined with Shuanghuanglian granules can effectively reduce the inflammatory reaction,ulcer status and pain degree in patients with recurrent oral ulcer,with a satisfactory efficacy,which is worthy of promotion.