术前应用氨溴索对左心室舒张功能不全老年患者开胸术后疗效研究

Study of curative effect on preoperative use of ambroxol in elderly patients with left ventricular diastolic dysfunction after thoracic surgeries

Objective: To investigate curative effect of preoperative use of ambroxol in elderly patients with left ventricular diastolic dysfunction after thoracic surgeries. Methods: Eighty eight cases of elderly patients in hospital were collected，who all had left ventricular diastolic dysfunction, but whose six minutes walking distance>300 m. The patients were divided into experimental group and control group, ambroxol were used pre-operation, while placebo were used in the control group. Static pulmonary function, Doppler ultrasound, C reactive protein (CRP), brain natriuretic peptide(BNP), procalcitonin(PCT) were detected 3 days before and after the operation ,8 days after operation. Vital signs and complications of heart and lung post operation were also monitored and analyzed. Results: The lung function and heart function in the experimental group were better than those in the control group, (P<0.05).The vital signs and arterial blood gas of the patients in the experimental group after the thoracic surgeries were more stable than those in the control group, P<0.05.Laboratorial index includes BNP,CRP ,PCT of the experimental group was lower than that in the control group, (P<0.05).The incidence of pulmonary infection ,pulmonary atelectasis, heart failure, arrhythmia in the experimental group after the thoracic surgeries were lower than that in the control group, （P<0.05）.Conclusion: Preoperative use of ambroxol can reduce the surgical trauma, improve heart and lung function in patients after the thoracic surgeries, as well as decrease the incidence of lung and heart complications. It also can help patients better adapt to the operation, leading to lower adverse effect.