血清铁蛋白检测在2型糖尿病患者中的应用价值

目的 探讨血清铁蛋白(SF)检测在2型糖尿病(T2DM)患者中的应用价值。 方法 选取2013年2月—2015年10月在海口市人民医院内分泌科就诊治疗的T2DM患者(T2DM组)120例，根据糖化血红蛋白(HbA1c)水平分为:疗效良好组(A组)53例和疗效差组(B组)67例，同时选取正常健康人员(NC组)60例，测定血清铁(SI)、血清铁蛋白(SF)、转铁蛋白(TRF)、HbA1c、空腹血糖(FPG)、空腹胰岛素(FINS)并计算胰岛素抵抗指数(HOMA-IR)与胰岛β细胞功能(HOMA β-cell)，比较T2DM组与NC组、A组与B组上述指标的变化，并分析其相关性。 结果 与NC组比较，T2DM组FPG、HbA1c、FINS、HOMA-IR、SF均升高(P＜0.05)，而HOMA β-cell降低(P＜0.05)；与A组比较，B组SF及HOMA-IR均升高(P＜0.05)，而HOMA β-cell降低(P＜0.05)；T2DM患者SF与HbA1c呈正相关(r=0.584，P＜0.05)、与HOMA-IR呈正相关(r=0.451，P＜0.05)、与HOMA β-cell呈负相关(r=-0.468，P＜0.05)。 结论 T2DM患者体内铁代谢紊乱，铁超载可能加重胰岛素抵抗及β细胞的损坏；SF可能是影响其疗效的重要因素，SF高者血糖难控制。 

The application value of serum ferritin in the Type 2 diabetes

Objective To explore the application value of serum ferritin in the Type 2 diabetes mellitus (T2DM) patients. Methods Choose from February,2013 to October,2015 in Haikou City People's Hospital of Endocrinology,diagnosis and treatment of patients with T2DM(T2DM group) 120 cases,according to glycated hemoglobin (HbA1c) levels are divided into:the efficacy of good group(A) and efficacy of 53 cases poor(group B) 67 cases,while selecting normal controls(NC) group,60 cases.Serum iron(SI),serum ferritin(SF),transferring(TRF),glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG) and fasting insulin(FINS) were determined and Calculated Insulin resistance index(HOMA-IR) and pancreatic β-cell function(HOMA β-cell) and compared the changes in T2DM group and NC group,group A and group B of the indicators and analysis of its relevance. Results Compared with the NC group,T2DM group FPG,HbA1c,FINS,HOMA-IR and SF were increased(P<0.05);Compared with group A,SF SF and HOMA-IR of group B all increased(P<0.05),HOMA β-cell decreased(P<0.05);T2DM patients with SF and HbA1c were positively correlated(r=0.584,P<0.05),positively correlated with HOMA-IR(r=0.451,P<0.05),and HOMA β-cell negative correlation(r=-0.468,P<0.05). Conclusion T2DM patients with iron metabolism disorders,iron overload may increase insulin resistance and β cell damage;SF may be an important factor affecting its efficacy,high SF is difficult to control blood glucose.