不同等级2所医院新生儿卡介苗接种效果及影响因素研究

目的了解常州市不同等级的2所医院新生儿卡介苗接种效果及其影响因素,为提高接种质量和人群免疫水平提供依据.方法 选择1个市级医院,1个县级医院作为哨点,监测2013年1~12月不同批次菌苗对符合条件新生儿的接种情况,3个月后进行结核菌素试验试验(PPD),观察硬结纵横径和直径,评价接种效果;采用Logistic回归模型,对接种效果进行多因素回归分析. 结果共接种卡介苗新生儿2254例,接种成功2090人,接种成功率92.7%.单因素分析显示,不同单位,季节,疫苗批次卡介苗接种成功率差异有统计学意义(P<0.05);金坛市人民医院接种成功率为95.15%,明显大于市妇幼保健院90.17%,差异有统计学意义(P < 0.05); 经组间比较,秋季接种成功率明显高于冬季(χ²=14.080, P = 0.000).疫苗批号201003a015-1接种成功率明显低于其他各批号,批号201003a012-2接种成功率明显低于批号201101a004-1和201012a083-2,差异均有统计学意义(均P = 0.000).多因素logistic回归分析,疫苗批号(OR=1.754,95%CI:1.477~2.084)是卡介苗接种成功的影响因素. 结论常州市市县不同等级医院新生儿卡介苗接种成功率均较高,疫苗不同批次是影响接种成功的影响因素.

Effect and influence factors of neonatal BCG vaccination of two hospitals in Changzhou

Objective To explore the effect and influence factors of neonatal BCG vaccination of two hospitals in Changzhou and improve BCG vaccination quality and immune level. Methodtwo different grade hospitals were collected as sentinel point to supervise BCG vaccination effect for newborns receiving various batches of BCG from Jan. to Dec. 2013. Participants were conducted PPD 3-months after BCG vaccination and were observed vertical and horizontal diameter of BCG harden to assess vaccination effect. Influence factors were analyzed by Logistic aggression. ResultsA total of 2254 cases of neonatal BCG vaccination were observed and the rate of the vaccination success was 92.7%. Univariate analysis showed that different units, season, vaccine batch were the factors influencing BCG vaccination success (P <0.05); the vaccination success rate of Jintan People's Hospital was 95.15%, significantly higher than that (90.17%) of Changzhou city women and child care hospital. the difference was significant (P <0.05). the vaccination success rate in autumn was significantly higher than that in winter (χ2 = 14.080, P = 0.000). the vaccination success rate inoculated with 201003a015-1 was significantly lower than other batches. the vaccination success rate inoculated with 201003a012-2 were significantly lower than those of the batch 201101a004-1 and 201012a083-2. The differences were statistically significant (all P = 0.000). Multivariate logistic regression showed revealed vaccine batche was the factor influencing BCG vaccination success(OR=1.754,95%CI:1.477~2.084). Conclusionsthe success rates of neonatal BCG vaccination of two different grade hospitals are high, and different vaccine batche is the risk factor of inoculation.