肺癌患者化疗前后生活质量情况及影响因素分析

目的 探讨肺癌患者化疗前后生活质量情况及影响因素。 方法 选择2012年1月—2014年12月在浙江省金华市广福医院呼吸科被诊断为晚期肺癌的患者86例作为研究对象，收集患者的病史资料，进行正规化疗治疗，在化疗前及化疗4个周期后进行EORTC QLQ-30问卷调查。观察肺癌患者化疗前后生活质量评分变化、肺癌患者的健康平均评分和影响因素的关系、肺癌患者的EORTC QLQ-30其它条目评分和影响因素的关系。 结果 晚期肺癌患者化疗4个周期后的躯体评分、情绪评分、社会评分、呼吸困难评分、总健康状况评分均明显低于化疗前(P＜0.05)，晚期肺癌患者化疗4个周期后的恶心呕吐评分、失眠评分、食欲减退评分、便秘腹泻评分均明显高于化疗前，差异有统计学意义(P＜0.05)，晚期肺癌患者的健康平均评分和患者的年龄、性别、病理类型、文化程度以及基础疾病之间差异无统计学意义(P＞0.05)。女性肺癌患者的食欲下降评分高于男性患者(P＜0.05)，60岁以上患者的食欲下降评分、便秘评分和恶心评分高于60以下患者(P＜0.05)，文化程度比较低的患者失眠评分高于文化程度比较高的患者(P＜0.05)，有基础疾病患者的疲倦评分高于无基础疾病患者(P＜0.05)，差异均有统计学意义。 结论 晚期肺癌患者化疗后躯体评分、情绪评分、社会评分、呼吸困难评分、总健康状况评分降低，恶心呕吐评分、失眠评分、食欲减退评分、便秘腹泻评分升高，晚期肺癌患者的生活质量情况和患者的性别、年龄、文化程度和是否合并基础疾病有关。 

Life quality situation and influencing factors of lung cancer patients before and after chemotherapy

Objective To investigate thelife quality situation and influencing factors of lung cancer patients before and after chemotherapy. Methods Total 86 lung cancer patients in our hospital between January 2012 and December 2014 were enrolled into thisstudy.Four cycles chemotherapy was carried out in all patients.EORTC QLQ-30 questionnaire was used to survey the quality of life,health average score and their relationship with the influencing factors. Results The physical score,moodscores,communityrating,dyspneascore,quality of life scores after four cycles chemotherapy were significantly lower than that before chemotherapy(P<0.05),the nausea and vomiting score,ratinginsomnia,loss of appetite score,constipation and diarrhea scores after four cycles chemotherapy were significantly higher than that before chemotherapy(P<0.05),the healthy average score of advanced lung cancer patients were no significant correlation with the age,gender,histological type,education level and the underlying disease(P>0.05).The anorexia score of female lung cancer patients was higher than males patients(P<0.05),the appetite score,constipation score,nausea score of patients aged over 60 were significantly higher than that of patients aged less than 60(P<0.05),the insomnia scores of patients with low educational level was significantly higher than that of patients with high education level (P<0.05),the fatigue scores of patients with underlying disease was higher than patients without underlying disease(P<0.05). Conclusion The physical score,mood scores,social score,dyspnea score,quality of life scores after chemotherapy in advanced lung cancer patients will decrease,and the nausea,vomiting score,insomnia score,loss of appetite score,constipation,diarrhea rates may increase.The quality of life in patients with advanced lung cancer is related with gender,age,and education level and basis diseases.