环孢素A药动学/药效学/不良反应的影响因素分析

目的：对影响环孢素A药动学、药效学、不良反应的药物因素及遗传因素进行分析。方法：主要查阅Pubmed、Embase及中国期刊全文数据库2010-2016年载录的相关文献，归纳总结出具体的影响因素。结果：药物因素（血药浓度、给药频率、合并用药等）及遗传因素（CYP3A和MDR1基因多态性等）对环孢素A药动学、药效学、不良反应均有影响。结论：基因多态性、合并用药为环孢素A药动学、药效学、不良反应的主要影响因素，临床上需结合患者实际情况进行监测以保证合理的个体化给药和用药安全。

Analysis of influential factors for pharmacokinetics/pharmacodynamics/adverse reactions of cyclosporine A

OBJECTIVE To analyze drug and genetic factors affecting pharmacokinetics,pharmacodynamics and adverse reactions of cyclosporine A (CsA).METHODS Information of interest was collected and summarized based on domestic and foreign relevant literatures in Pubmed,Embase and CNKI from 2010 to 2016.RESULTS Drug factors including concentration,medication frequency,drug interactions,and genetic factors including MDR1 and CYP3A polymorphisms of recipients,were the relevant factors.CONCLUSION Major factors affecting clinical efficacy of CsA are polymorphisms of recipients and drug interactions.Therefore,real conditions of patients should be taken into account to timely monitor to realize individualized medication and ensure medication safety.