帕金森病患者血清半胱氨酸蛋白酶抑制剂C水平的变化及其临床意义

目的 探讨血清半胱氨酸蛋白酶抑制剂C (胱抑素C,Cys-C)水平与帕金森病患者(Parkinson’s disease,PD)的相关性及临床意义。 方法 收集70例PD患者为观察组(PD组)，30例健康体检者为对照组，根据Hoehn-Yahr (修正)分级量表(H&Y分期)将PD组分为3个亚组:早期组25例、中期组24例和晚期组21例。应用免疫比浊法检测血清Cys-C水平，比较PD组与对照组血清Cys-C水平的差异及PD组各亚组间血清Cys-C水平的差异；同时分析血清Cys-C与H&Y分期及帕金森病评定量表(UPDRS)运动评分的相关性。 结果 PD组患者血清Cys-C水平明显高于对照组，差异具有统计学意义(t=3.61,P＜0.01)；晚期组血清Cys-C水平明显高于中期组及早期组，差异具有统计学意义(P＜0.05,P＜0.01)；中期组血清Cys-C水平明显高于早期组及对照组，差异具有统计学意义(P＜0.01,P＜0.01)；早期组血清Cys-C水平高于对照组，但差异无统计学意义(t=1.31,P=0.12)。PD组血清Cys-C水平与H&Y分期(r=0.67,P＜0.01)、UPDRS Ⅱ(r=0.64,P＜0.01)及UPDRS Ⅲ(r=0.59,P＜0.01)均呈正相关。 结论 PD患者血清Cys-C水平升高，且血清Cys-C水平与PD的病程进展相关，可反应病情的严重程度，在PD的进展中起一定作用。 

The clinical significance of serum cystatin C level change in Parkinson's disease

Objective To investigate the correlation and clinical significance between serum cystatin C (Cys-C) level and Parkinson's disease(PD). Methods Seventy patients of PD were selected as the observation group(PD g-roup),30 healthy people were selected as the control group,PD group was divided into three subgroups according to the score of H&Y staging:early stage group(25 cases),medium stage group(24 cases)and advanced stage group(21 cases).A immunology turbidimetric was employed to measure the serum Cys-C levels.Compare the PD group and control group differences in the levels of serum Cys-C,and compare PD group each subgroup differences in the levels of serum Cys-C.At the same time,the correlation between serum Cys-C levels and gender,age,H&Y staging and U-PDRS motor score were analyzed. Results The serum level of Cys-C was significantly higher in PD group than the control group,the difference is statistically significant (t=3.61,P<0.01);the serum level of Cys-C was significantly higher in the advanced stage group than in the medium stage group and early stage group,the differences are statisticallysignificant(P<0.05,P<0.01);the serum level of Cys-C was significantly higher in the medium stage group than in the early stage group and control group,the differences are statistically significant(P<0.01,P<0.01);the serum level of Cys-C was higher in the early stage group than in the control group,but the difference was not statistically significant(t=1.31,P=0.12>0.05).Pearson correlation analysis revealed the serum Cys-C level of the PD group had a positive correction with H-Y stage(r=0.67,P<0.01),UPDRS Ⅱ score(r=0.64,P<0.01),UPDRS Ⅲ score(r=0.59,P<0.01). Conclusion The serum level of Cys-C was significantly higher in PD than the control group;The serum Cys-C levels associated with the progression of PD,can reflect the severity of the disease and play a role in the development of PD.