DDST用于维族婴幼儿筛查效度的探索性研究

目的:研究丹佛发育筛查测验(DDST)用于维族婴幼儿的筛查效度。方法:80名未见躯体疾病的维族婴幼儿纳入研究。以格塞尔发育诊断量表（Gesell）为效标，进行Gesell和DDST的个别测试。效度评价采用灵敏度、特异度、假阳性率、假阴性率、符合率和工作特征曲线下面积(AUC)。结果:DDST迟缓筛查率为17.50%，语言能区迟缓率最高，占比达56.00%。以Gesell发育商DQ≤75分为切点时，DDST筛查的灵敏度、特异度、假阳性率、假阴性率和符合率分别为100.00%、85.71%、14.29%、0.00%和86.25%，AUC为0.93(P<0.01)。以Gesell发育商DQ<85分为切点时，DDST的灵敏度、特异度、假阳性率、假阴性率和符合率分别为69.23%、92.54%、7.46%、30.77%和88.75%，AUC为0.80(P<0.01)。结论:用于筛查Gesell异常诊断的维族婴幼儿时，DDST具有较高筛查价值；用于筛查Gesell可疑诊断的婴幼儿时，DDST筛查能力中等。语言可能影响了DDST的筛查效度，可考虑建立维族常模。

Validity research on Denver Development Screening Test applied to Uygur children

Objective: To research the screening validity of the Denver Development Screening Test（DDST）used in Uygur children. Methods: A total of 80 physically healthy Uygur children were enrolled. Gesell Developmental Scales was used as the validity criterion. Both DDST and Gesell were measured in all subjects. The sensitivity, specificity, coincidence rate and area under the ROC curve(AUC) were used as the validity indexes. Results: When used in Uygur children, it showed language retarded rate was higher than other factors. DDST has a high detecting rate for subjects diagnosed as abnormal development by Gesell, with the sensitivity of 100%, the specificity 85.7% the coincidence rate 86.3% and AUC 0.93(p<0.01). While the sensitivity was 69.2%, the specificity was 92.5%, the coincidence rate was 88.8% and AUC was 0.80(p<0.01) when used for screening suspicious abnormal children. Conclusion: DDST has a high screening value in detecting Uygur children who might be diagnosed with abnormal development by Gesell. When it comes to children diagnosed as suspicious abnormal, DDST screening ability would drop to moderate. Language might be an influential factor affecting the outcome. Furthermore, it is essential to consider the necessity of establishing a Uygur norm