微生态制剂及抗菌肽在龋病防治中的研究进展

龋病是以细菌因素为主的多种因素引起的口腔微生态失衡为特征的口腔慢性感染性疾病,是人类最常见的细菌性疾病^[1,2]。目前龋病预防的关注点集中于对牙菌斑的去除,而牙菌斑实则为大量共生微生物集中组成,因此"移除或杀灭所有"菌斑微生物的理念对于致病微生物创造了一个开放的非竞争性的环境。传统的方法预防或治疗龋病,无法从根本上解决牙体组织损伤及细菌耐药性等问题。微生态制剂及抗菌肽应运而生,通过抑制口腔病原菌毒性作用以达到调节口腔微生态平衡的目的,是预防及治疗龋病的新方法。

Research Progress of Probiotics and Antimicrobial Peptides in Caries Prevention

Dental caries, the most common bacterial diseases for mankind, is oral chronic infection disease that under the combined action of various factors to bacterial factors and is characterized by oral microbial ecology imbalance. Because dental plaque is prerequisites of caries, at present, the focus of dental caries prevention is still concentrated in removing dental plaque that is composed of a large number of symbiotic microorganisms actually. Therefore, an idea to "remove or kill" all the microorganisms in dental plaque oppositely creates an open and non-competitive environment for pathogenic microorganisms. People gradually realize that the traditional method of prevention or treatment of dental caries is unable to fundamentally solve not reversible tooth tissue damage and bacterial resistance. Probiotics and antimicrobial peptide are present at the right moment. They regulate the oral microbial ecology balance through the inhibition of toxic effects of oral pathogenic bacteria. Now, it has become the new method to prevent and treat dental caries.