奥沙西泮联合黛力新治疗49例脑卒中后抑郁的疗效及预后研究

目的 观察奥沙西泮联合黛力新对脑卒中后抑郁的疗效及预后情况。 方法 选择绍兴市立医院于2012年10月—2015年1月收治的98例脑卒中住院患者，随机分为观察组和对照组各49例。2组皆进行常规心理治疗，对照组在此基础上用黛力新治疗；观察组在常规治疗基础上予奥沙西泮联合黛力新治疗。2组疗程4周，比较2组疗效、不良反应发生率、治疗前后HAMD评分、临床神经功能缺损(NDS)评分、日常生活能力(BI)评分。 结果 观察组的总有效率为96.0%，明显高于对照组的81.6%，差异有统计学意义(P＜0.05)。2组不良反应差异无统计学意义(20.4% vs. 18.4%，P＞0.05)。治疗4周后，观察组的HAMD评分显著低于对照组(13.8±2.8 vs. 17.6±3.2)，差异有统计学意义(P＜0.05)；观察组的NDS评分也显著低于对照组(6.8±2.4 vs. 10.7±3.5)，差异有统计学意义(P＜0.05)；观察组的BI评分显著高于对照组(74.9±14.4 vs. 61.3±14.2)，差异有统计学意义(P＜0.05)。 结论 采用奥沙西泮联合黛力新治疗脑卒中后抑郁症患者疗效稳定，副作用较低，并发症少，并可显著减轻临床神经功能缺损及改善患者生活能力，值得在临床推广应用。 

Curative effect and prognosis of Oxazepam combined with Deanxit in the treatment of 49 cases of post-stroke depression

Objective To observe and analyze the curative effect and prognosis of oxazepam combined with Deanxit (Flupentixol and Melitracen Tablets) on the post-stroke depression. Methods Total 98 inpatients from October,2012 to January,2015 were randomly divided into observation group and control group with 49 cases in each group.On the basis of routine psychological and drug treatment,the patients in the control group received Deanxit while the observation group received oxazepam combined with Deanxit for 4 weeks,then the curative effect,adverse reaction rate,HAMD17 scale score,clinical neurological function defect(NDS) score,Barthel index(BI) score before and after 2 and 4 weeks of treatment were compared. Results The total effective rate in the observation group was 96.0%,significantly higher than that in the control group(81.6%),the difference was statistically significant(P<0.05).There was no significant difference in adverse reactions between the two groups(20.4% vs. 18.4%),P>0.05.After 4 weeks treatment,the HAMD scale score in the observation group was significantly lower than that of the control group(13.8±2.8 vs. 17.6±3.2),it was statistically significant(P<0.05);NDS score in the observation group was significantly lower than that of control group(6.8±2.4 vs. 10.7±3.5),it was statistically significant(P<0.05);the BI score of the observation group was significantly higher than that of the control group(74.9±14.4 vs. 61.3±14.2),it was statistically significant(P<0.05). Conclusion Oxazepam combined with Deanxit for the post-stroke depression is remarkably stable,has low side effect,less complications and can significantly reduce the clinical neural function defect and improve the ability of living,it is worth spreading in clinical practice.