| 脂肪代谢与肿瘤 |
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| 引用本文： | 梁蓓蓓,薛邦德,刘箐,陈锐,何培忠.脂肪代谢与肿瘤[J].肿瘤防治研究,2016,43(6):531-533. |
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| 作者姓名： | 梁蓓蓓 薛邦德 刘箐 陈锐 何培忠 |
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| 作者单位： | 1. 200933 上海，上海健康医学院医学影像学院；2. 200933 上海，上海理工大学系统生物研究中心；3. 200025 上海，上海交通大学附属瑞金医院心脏外科；4. 200433 上海，第二军医大学国际肿瘤研究所 |
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| 基金项目： | 国家自然科学基金（81402030）; 上海市青年教师资助计划项目（slg14064） |
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| 摘 要： | 脂肪代谢是机体内非常重要的代谢途径之一，其在细胞内环境稳态的维持上发挥着不可忽视的作用。机体脂肪代谢主要由脂肪酸代谢和脂滴代谢组成。越来越多的研究显示脂肪代谢与肿瘤的发生发展有着一定的关系，其中脂肪酸代谢对于恶性肿瘤微环境的维持至关重要，而脂滴代谢更是参与了多种恶性肿瘤的发生和发展。本文就脂肪代谢与肿瘤之间的关系及其相关机制作一综述，探讨脂肪代谢在肿瘤研究中的作用和意义。
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| 关 键 词： | 肿瘤 脂肪代谢 脂肪酸 脂滴 |
| 收稿时间： | 2015-09-30 |
Lipid Metabolism and Cancer |
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| LIANG Beibei,XUE Bangde,LIU Qing,CHEN Rui,HE Peizhong.Lipid Metabolism and Cancer[J].Cancer Research on Prevention and Treatment,2016,43(6):531-533. |
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| Authors: | LIANG Beibei XUE Bangde LIU Qing CHEN Rui HE Peizhong |
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| Institution: | 1. The School of Medical Imaging, Shanghai University of Medicine and Health Sciences, Shanghai 200933, China; 2. Biology Research Center, University of Shanghai for Science and Technology, Shanghai 200933, China; 3. Department of Cardiovascular Surgery, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;4. International Joint Cancer Research Institute, The Second Military Medical University,Shanghai 200433, China |
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| Abstract: | Lipid metabolism is one of the most important metabolic pathways in the organism, and it plays central roles in the homeostasis. Fatty acid and lipid droplets are two processes in lipid metabolism. More and more researches confirmed that it had certain relationship between lipid metabolism and the proliferation of can cers. Recent studies have demonstrated that the microenvironment of cancer cells is affected by the unsaturated lipids metabolism. Lipid droplets proteins are involved in the occurrence and development of malignant tumors. In this review, we will summarize the relationship between lipid metabolism and cancer development, and the potential mechanism under them, and explore the significance of lipid metabolism and cancer. |
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| Keywords: | Cancer Lipid metabolism Fatty acid Lipid droplets |
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