埃索美拉唑、多潘立酮与铝碳酸镁联合治疗胆汁反流性胃炎的临床疗效

目的 通过观察埃索美拉唑、多潘立酮与铝碳酸镁联合治疗对胆汁反流性胃炎(BRG)临床症状及电子胃镜下胃黏膜的影响，评价其临床疗效。 方法 90例BRG患者按照完全随机数字表法随机分为观察组和对照组，每组45例。对照组给予多潘立酮、铝碳酸镁治疗，观察组在上述治疗基础上联合埃索美拉唑。观察比较2组的临床症状、胃内吸出物和胃镜下黏膜情况。 结果 2组患者年龄、性别、病程、临床症状等资料比较差异无统计学意义(P＞0.05)。2组患者治疗前各症状评分比较差异无统计学意义(P＞0.05)。治疗后，2组各症状评分均较治疗前显著改善，且观察组降低程度显著优于对照组(P＜0.05)。治疗后，观察组的胃液胆酸含量、胃酸分泌量分别为(85.13±61.64)mg/ml，(1.31±0.27)mmol/h，均显著低于对照组的(136.28±92.36)mg/ml，(2.81±0.54)mmol/h(P＜0.05)。治疗后胃镜下观察2组患者胃黏膜充血、水肿、糜烂、粘液湖胆染等情况均明显改善。观察组的胃黏膜充血、水肿、糜烂评分分别为(0.82±0.29)、(0.56±0.16)、(0.62±0.15)分，对照组的胃黏膜充血、水肿、糜烂评分分别为(1.38±0.32)、(1.53±0.18)、(1.36±0.19)分，2组差异均具有统计学意义(P＜0.05)。 结论 埃索美拉唑、多潘立酮、铝碳酸镁在BRG的治疗上有协同作用，联合使用可更好地改善临床症状，保护胃黏膜。 

Clinical efficacy of combined therapy with Esomeprazole,domperidone and hydrotalcid in patients with bile reflux gastritis

Objective To evaluate the clinical efficacy of the combined therapy withesomeprazole,domperidone and hydrotalcid in patients with bile reflux gastritis(BRG)by observing the clinical symptoms and electronic gastroscopy. Methods Total 90 cases of BRG were randomly divided into control group and observation group according to a completely random number table,45 cases in each group.The control group received domperidone and aluminum magnesium treatment,while the observation group received the combined therapy with esomeprazole,domperidone and hydrotalcid.The clinical symptoms,bile reflux and the condition of the gastric mucosa by the gastroscopy were compared between the two groups. Results There was no statistically significant difference in age,gender,disease duration,clinical symptoms and bile regurgitation,etc.between the two groups(P>0.05).After the treatment,the symptom score of both groups were improved significantly as compared with those before the treatment,and the score of the observation group decreased more significantly than the control group(P<0.05).After the treatment,the gastric acid content and gastric acid secretion of the observation group was (85.13±61.64) mg/ml and (1.31±0.27) mmol/h,respectively,which were significantly lower than (136.28±92.36) mg/ml and (2.81±0.54) mmol/h of the control group(P<0.05).After the treatment,gastric mucosal congestion,edema,erosion,lake bile stained mucus cases were significantly improved in both groups,and the degree of improvement in observation group was more obvious as compared with the control group(P<0.05).Gastric congestion,edema,erosion score of observation group was (0.82±0.29),(0.56±0.16) and (0.62±0.15) points,respectively,and of the control group was(1.38±0.32),(1.53±0.18) and (1.36±0.19) points,respectively,the differences were statistically significant(P<0.05). Conclusion The combined therapy with esomeprazole,domperidone and aluminum magnesium carbonate in patients with bile reflux gastritis has a synergistic effect,which will better improve the clinical symptoms and protect the gastric mucosa.