左氧氟沙星致过敏性休克64例文献分析

目的：探讨左氧氟沙星致过敏性休克的临床特点及相关因素，为安全用药提供参考。方法：对2006年至2015年国内公开报道的64例左氧氟沙星致过敏性休克病例报告进行统计分析。结果：64例休克患者年龄分布主要介于21~50岁（67.19%），男性明显多于女性。用药途径以静脉滴注为主（92.19%），给药剂量集中于200~400 mg （73.44%）。发生于30 min以内的速发型过敏性休克占76.56%。休克患者恢复时间与用药类型没有关系，但与血压的高低有关。舒张压越低，恢复时间越长（r_s=-0.389，P=0.003）。不同舒张压患者恢复时间的差异有统计学意义（H=11.151，P=0.004，0~20 mmHg组患者恢复时间明显长于21~40 mmHg组（Z=2.274，P=0.023）和41~60 mmHg组（Z=3.116，P=0.002）。结论：左氧氟沙星致过敏性休克日益多见，且速发型比例较高，应尽早发现及快速救治。

Literature analysis on 64 cases of anaphylactic shock caused by levofloxacin

OBJECTIVE To discuss characteristics and correlation factors of anaphylactic shock induced by levofloxacin, and provide a reference for clinical safe drug use.METHODS Clinical data of shock induced by levofloxacin in 64 cases publicly reported in China from 2006 to 2015 were statistically analyzed.RESULTS A total of 64 cases of shock were mainly distributed in ages between 21 and 50 years old (67.19%). More males were included than females. Administration route was dominated by intravenous drip (92.19%), dose range was concentrated on 200-400 mg (73.44%). Immediate anaphylactic shock within 30 min accounted for 67.19%. Recovery time of shock patients was not related to type of used drug, but related to blood pressure. Lower diastolic blood pressure, longer recovery time (r_s=-0.389, P=0.003). There was statistical significance in the recovery time of patients with different diastolic pressures (H=11.151, P=0.004). Recovery time of patients in 0-20 mmHg group was significantly longer than that in 21-40 mmHg group (Z=2.274, P=0.023) and 41-60 mmHg group (Z=3.116, P=0.002).CONCLUSION Anaphylactic shock caused by levofloxacin is becoming more and more frequent, rate of the immediate type is higher, which should be observed and treated quickly.