宫颈癌预后相关分子标志物的研究进展

宫颈癌是女性最常见的恶性肿瘤之一，严重影响女性健康，尤其以发展中国家更甚。其导致死亡的主要原因是局部复发和转移，因此，选择合理治疗方案，准确评估其预后，减少复发转移是降低宫颈癌死亡率的关键。目前宫颈癌的预后评估指标主要包括FIGO分期、淋巴结转移、间质浸润深度、肿瘤大小、脉管瘤栓等高危因素，但这些临床病理特征在预后评估方面尚不够精准，有必要寻找新的预后标志物来准确指导治疗。近年来肿瘤分子标志物被广泛研究，部分与预后有相关性的分子标志物已逐渐被证实。本文综述与宫颈癌预后相关的分子标志物的现况，旨在为后续研究开拓新思路，为宫颈癌的综合治疗提供更为合理依据。

Advance of Prognostic Markers of Cervical Cancer

Cervical cancer is one of the most common malignancies in female, seriously affecting the health of women, particularly in developing countries. The main cause of death is local recurrence and metastasis. Therefore, the selection of reasonable treatment plans, accurate assessment of the prognosis, and reducing the recurrence and metastasis are the keys to reduce the mortality of cervical cancer. Currently the main prognostic markers of cervical cancer include FIGO stage, lymph node metastasis, interstitial infiltration, tumor size, vascular invasion, but these clinical pathological features are not accurate enough in prognosis evaluation. So, we need to find new prognostic markers to accurately guide the treatment. In recent years, molecular tumor markers had been extensively studied, and some molecular markers associated with the prognosis have been confirmed. This article reviews the current status of molecular markers related to the prognosis of cervical cancer, and aims to explore new ideas for the follow-up study and provide a more reasonable basis for the treatment of cervical cancer.