美国医学会杂志（JAMA）2000-2014年发表的眼科文章分析

目的 对美国医学会杂志（The Journal of American Medical Association， JAMA）自2000-2014年收录的眼科方面的文献进行检索和阅读，以了解眼科临床研究的热点问题及研究方向。设计 文献检索分析。研究对象 JAMA杂志2000年1月至2014年2月期间发表的文章。方法 在Pubmed数据库中，MeSH Terms输入“eye”及其所有下位主题词，选择杂志“JAMA”，检索出JAMA收录的眼科相关文献，通过阅读摘要及部分精简全文进一步筛选。主要指标 文献种类。结果 共获得眼科相关文献92篇。按文章类型分类，包括论著26篇（28.3%）、述评38篇（41.3%）、通信6篇（6.5%）、综述10篇（10.9%，其中系统评价1篇）及病例报告12篇（13.0%）。 按研究内容分类，包括病因及危险因素30篇（32.6%）、治疗14篇（15.2%）、疾病综合评价21篇（22.8%）。按研究类型分类，26篇论著中有队列研究8篇、纵向研究6篇、横断面调查5篇、病例对照研究3篇、随机对照试验3篇（其中多中心随机对照试验1篇）及其他1篇。按作者国家和地区分类，美国最多为58篇（63.0%），其次为英国和加拿大各6篇（6.5%），中国大陆1篇述评，中国台湾1篇病例报告。按疾病分类，年龄相关性黄斑变性的文献最多为14篇（15.2%），多为探讨其病因及危险因素（6篇）；其次为白内障13篇（14.1%），多关于手术预后（7篇）。视网膜脱离和糖尿病视网膜病变的文献分别10篇（10.9%）和9篇（9.8%）。结论 JAMA杂志在眼科领域重点关注年龄相关性黄斑变性等眼底病的病因和治疗以及白内障的手术预后等，方法学相应偏重于队列研究、纵向研究和横断面调查，美国发表文献最多，体现出明显的地域特色。（眼科，2016, 25： 418-422）

Analysis of articles on ophthalmology published in JAMA from the year 2000 to 2014

Objective To understand the hot spots and breakthrough on ophthalmology by searching and reading articles published in The Journal of American Medical Association（JAMA） from the year 2000 to 2014.  Design Literature search and analysis．Participants Articles on ophthalmology were published from Jan. 2000 to Feb. 2014 in JAMA. Methods In Pubmed database, we chose the database “JAMA” and then selected “MeSH Terms” and inputted “eye” and all its inferior MeSH terms. Further screening was done by reading titles and abstracts of the articles as well as reading the necessary part of the full article. Main Outcome Measures Literature types. Results Among 92 included articles, 26 (28.3%) were original articles，38 (41.3%) were comments, 6 (6.5%) were letters, 10(10.9%) were reviews and 12(13.0%) were case reports． When classified by research content, 30 (32.6%) articles were mainly about etiology and risk factors, 14 (15.2%) were about treatment and 21(22.8%) were about comprehensive evaluation of disease. According to research type of the 26 original articles, 8 articles were cohort study, 6 articles were longitudinal study, 5 articles were cross-sectional study, 3 articles were case-control study, 3 articles were RCTs (including one multicenter randomized controlled trial) and another one paper. In terms of the nationality of authors, American accounted for 58 (63.0%) pieces, Britain and Canadian both accounted for 6 (6.5%) pieces, Chinese accounted for 1 (1.1%) comment, Chinese in Taiwan accounted for 1 (1.1%) case report and others accounted for 20 (21.7%) pieces. As for disease types, the most concerned disease was age related macular degeneration (AMD), accounting for 14 (15.2%) pieces and 6 articles of them were about etiology and risk factors of AMD. Following was about cataract, accounting for 13 (14.1%) pieces and 7 articles were about prognosis of operation. Retinal detachment accounted for 10 (10.9%) pieces while diabetic retinopathy accounted for 9 (9.8%) pieces.  Conclusion The focus of JAMA in ophthalmology was on etiology and treatment of retinal disease like AMD and prognosis of cataract operation. While in methodology, cohort study, longitudinal study and cross-sectional study were most often used. What’s more, it showed obvious local characteristics that most papers were published by American authors. (Ophthalmol CHN， 2016, 25： 418-422)