ASPP调控肿瘤细胞凋亡作用的研究进展

p53基因作为机体重要的凋亡调控因子，在受到致癌因素刺激后可诱导细胞出现细胞周期阻滞或凋亡。细胞凋亡或程序性死亡过程受到干扰或破坏时，可引起细胞异常增殖及恶性转化而导致肿瘤的发生。近期研究发现了一类新的p53相互作用蛋白ASPP家族，它们能够特异性调控p53家族分子的细胞凋亡诱导功能，揭示了p53诱导细胞凋亡的新机制，为脊柱肿瘤发生和靶向治疗研究提供了新思路。本文针对ASPP基因结构特点、调控肿瘤细胞凋亡作用和其临床意义等方面的研究进展进行综述。

Research Advances of ASPP in Regulating Apoptosis of Tumor Cells

Under the stimulus of carcinogenic factor, p53 acts as an important apoptotic regulator to induce the cell cycle arrest or apoptosis. When the progress of cell apoptosis or programmed death is disturbed or damaged, the abnormal proliferation, malignant transformation of cells are initiated, which lead to the tumorigenesis. Recent studies have found a new gene family named ASPP which could interact with p53 family and specifically regulate the apoptosis function of p53 molecules. The findings reveal a new apoptosis regulating mechanism of p53 and provide a novel research strategy of the spinal tumorigenesis and their targeted therapy. In this paper, we aim to review the recent advances about the structure characteristics of ASPP genes, their apoptosis regulation effect on tumor cells, and the clinical significance in the diagnosis and therapy of tumors.