中药大黄对正畸固定矫治中龈炎的治疗研究

目的:评价中药大黄对正畸固定矫治中龈炎治疗的临床疗效。方法:选择牙周健康者20例(尚未矫治)和矫治6个月临床诊断为牙龈炎的患者60例为研究对象,牙周健康患者20例设为牙周健康组,60例牙龈炎患者随机分为3组:大黄组、明胶海绵组和对照组。分别于治疗前采集4组研究对象的牙周临床指数和龈沟液标本,使用ELISA法测量龈沟液中白介素-1β的含量,比较组间各项指标间的差异。对牙龈炎3组患者,其中大黄组用大黄明胶海绵药条,明胶海绵组用灭菌蒸馏水明胶海绵条,分别置于龈袋内,每周上药1次,共4次,对照组患者龈袋内不放任何药物。于4周后重新采样比较牙周治疗前后上述指标间的差异。结果:牙龈炎组治疗前牙周临床指数、龈沟液IL -1β浓度均显著高于牙周健康组(P＜0.05),大黄组、明胶海绵组与对照组比较无显著性差异。治疗后明胶海绵组上述指标与对照组比较无显著性差异,且明显高于牙周健康组(P＜0.05)。治疗后明胶海绵组和对照组分别与治疗前比较均无显著性差异。治疗后大黄组上述指标相比治疗前及对照组均明显降低(P＜0.05),与牙周健康组比较,龈沟出血指数(SBI)接近正常。结论:中药大黄对正畸固定矫治中龈炎具有明显的治疗效果。

Effect of Rhubarb on the Treatment of Gingivitis in Orthodontic Fixed Treatment

Objective: To investigate the effect of rhubarb on the treatment of gingivitis in orthodontic fixed treatment. Methods: The study sample included 20 periodontal healthy controls and 60 patients with gingivitis undergoing orthodontic fixed treatment for six months. Sixty patients with gingivitis were randomly divided into 3 groups: rhubarb group, gelatin sponge group and control group. Before treatment, clinical periodontal index and gingival cervical fluid (GCF) samples were taken from both the periodontal healthy control group and gingivitis groups. GCF interleukin IL- 1β was detected by ELISA. Data was compared among four groups. In the rhubarb group and the gelatin sponge group, rhubarb gelatin sponge and gelatin sponge were put respectively into the gingival pockets once a week and nothing for control group. After 4 weeks, all the parameters were reassessed. Results: Before treatment, clinical periodontal index and concentration of GCF IL - 1β of gingivitis groups were significantly higher than those of the periodontal health group (P<0.05), the rhubarb group and the gelatin sponge group had no significant difference when compared with the control group. After treatment, indices of the gelatin sponge group showed no significant difference compared to the control group, and was significantly higher than the periodontal health group (P<0.05). After treatment, indices of the gelatin sponge group and control group exhibited no significant difference when compared to the pre-treatment results (P<0.05).The indices of the rhubarb group were all significantly decreased after treatment (P<0.05), while compared with the periodontal health group, the rhubarb group gingival sulcus bleeding index ( SBI ) was close to normal (P<0.05). Conclusion: The use of rhubarb is effective in control of gingivitis in orthodontic fixed treatment.