EPOCH方案中依托泊苷、盐酸多柔比星和硫酸长春新碱的配伍稳定性

目的：考察EPOCH方案中3种药物在0.9%氯化钠溶液中的配伍稳定性，为临床使用该方案提供理论依据。方法：模拟临床给药浓度配制EPOCH方案混合输液，其中依托泊苷（VP-16）质量浓度为175 μg·mL^-1，盐酸多柔比星（ADM）质量浓度为35 μg·mL^-1，硫酸长春新碱（VCR）质量浓度为1.4 μg·mL^-1，用高效液相色谱法测定混合输液36 h内的各成分含量及不溶性微粒数变化，pH计测定pH值。结果：所建立的HPLC检测方法简单，可靠，稳定，应用此法对EPOCH方案中配伍的3种药物浓度和pH进行检测，结果显示3种成分的浓度和溶液的pH值在36 h内基本未发生变化。结论：EPOCH方案中3种化疗药物按照临床使用浓度配伍，在500 mL生理盐水中相容且稳定，此配伍输注方法临床应用安全可靠。

Compatible stability of vincristine sulfate,doxorubicin hydrochloride and etoposide phosphate in EPOCH regimen

OBJECTIVE To evaluate compatible stability of etoposide phosphate,vincristine sulfate and doxorubicin hydrochloride in admixtures prepared with 0.9% sodium chloride injection at concentrations simulating those used in the EPOCH chemotherapy regimen,and provide a theoretic reference for clinical medication.METHODS Concentrations were simulated for three drugs in EPOCH chemotherapy regimen,in which etoposide phosphate was 175 g·mL^-1,vincristine sulfate was 35 g·mL^-1 and doxorubicin hydrochloride was 1.4 g·mL^-1,then pH value was determined,contents of different components and insoluble particles within 36 hours were estimated with high performance liquid chromatography.RESULTS HPLC method was simple,reliable and stable.The pH value of the admixtures stored within 36 hours and concentration of each component had not changed significantly,indicating that these drugs were physically compatible in the admixtures.CONCLUSION Etoposide phosphate,doxorubicin hydrochloride and vincristine sulfate in 500 mL of 0.9% sodium chloride injection at concentrations common in EPOCH chemotherapy regimen,are compatible and stable,which is safe and reliable for clinical use.