| 乌药总生物碱抗炎镇痛药理学研究 |
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| 引用本文： | 张剑,罗人仕,杨瑜,刘冰晶.乌药总生物碱抗炎镇痛药理学研究[J].中国医院药学杂志,2016,36(24):2187-2190. |
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| 作者姓名： | 张剑 罗人仕 杨瑜 刘冰晶 |
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| 作者单位： | 1. 赣南医学院药学院, 江西 赣州 341000;
2. 江西省脑血管药理重点实验室, 江西 赣州 341000;
3. 赣南医学院第三附属医院, 江西 赣州 341000 |
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| 基金项目： | 江西省教育厅科技重点项目（编号：GJJ10698）；江西省教育厅科技项目（编号：GJJ11565）；江西省卫生厅中医药科研计划（编号：2011A153） |
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| 摘 要： | 目的：对乌药总生物碱抗炎镇痛作用进行研究。方法：采用p-二甲苯致小鼠耳廓肿胀法和角叉菜胶致后足跖肿胀法、小鼠热扳法和乙酸致小鼠扭体法等方法来评估用索氏法氨水-氯仿提取得到的乌药总生物碱的抗炎镇痛效果。结果：乌药总生物碱有缓解p-二甲苯致小鼠耳廓肿胀及角叉菜胶致后足跖肿胀效果，能减少小鼠在热板上舔后足的次数和减少乙酸致小鼠扭体的次数，镇痛效果显著。结论：乌药总生物碱抗炎镇痛作用明显。
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| 关 键 词： | 乌药 总生物碱 抗炎 镇痛 |
| 收稿时间： | 2016-03-17 |
Pharmacology research on anti-inflammatory and analgesic effects of total alkaloids from Linderae Radix |
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| ZHANG Jian,LUO Ren-shi,YANG Yu,LIU Bing-jing.Pharmacology research on anti-inflammatory and analgesic effects of total alkaloids from Linderae Radix[J].Chinese Journal of Hospital Pharmacy,2016,36(24):2187-2190. |
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| Authors: | ZHANG Jian LUO Ren-shi YANG Yu LIU Bing-jing |
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| Institution: | 1. College of Pharmacy, Gannan Medical University, Jiangxi Ganzhou 341000, China;
2. Jiangxi Provincial Key Lab of Cerebrovascular Pharmacology, Jiangxi Ganzhou 341000, China;
3. Third Affiliated Hospital of Gannan Medical University, Jiangxi Ganzhou 341000, China |
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| Abstract: | OBJECTIVE To study anti-inflammatory and analgesic effects of total alkaloids from Linderae Radix. METHODS The anti-inflammatory and analgesic effects of total alkaloids extracted from Linderae Radix by Soxhlet method with the ammonia and chloroform as the solvents, were observed by p-xylene-induced mouse ear swelling method, carrageenan-induced paw swelling method, hot plate method and acetic acid writhing method in mice. RESULTS Total alkaloids from Linderae Radix could obviously relieve mice ear swelling and carrageenan-induced paw swelling, significantly reduce the hind licking times and decrease acid-induced mouse writhing times. The analgesic effect of Linderae Radix was exact. CONCLUSION Linderae Radix has obvious analgesic and anti-inflammatory effects in mice. |
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| Keywords: | Linderae Radix total alkaloids anti-inflammatory analgesia |
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