| 狗肝菜多糖颗粒剂成型工艺的优选 |
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| 引用本文： | 许有瑞,高雅,张可锋,钟明利,林家逊.狗肝菜多糖颗粒剂成型工艺的优选[J].中国医院药学杂志,2016,36(24):2141-2144. |
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| 作者姓名： | 许有瑞 高雅 张可锋 钟明利 林家逊 |
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| 作者单位： | 桂林医学院药学院, 广西 桂林 541004 |
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| 基金项目： | 国家自然科学基金（编号：81360685）；广西科技攻关项目（编号：14124004-2-13）；广西自然科学基金（编号：2014GXNSFBA118149）；广西壮族自治区卫生和计划生育委员会中医药科技专项（编号：GZBZ16-15） |
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| 摘 要： | 目的：优选狗肝菜多糖颗粒剂的最佳成型工艺条件。方法：以颗粒成型率、流动性与溶化性为考察指标，分别用单因素试验和正交试验优选颗粒剂处方中所用辅料（填充剂与黏合剂）的种类及其用量，并对制得的颗粒剂进行质量检查。结果：最佳成型工艺条件为狗肝菜多糖-甘露醇-3%HPMC水溶液=1：2.5：0.035，所制得的颗粒剂粒度、流动性与溶化性等项目检查都符合《中国药典》要求。结论：优选出的狗肝菜多糖颗粒剂成型工艺可行，可为进一步工业化生产提供参考和依据。
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| 关 键 词： | 狗肝菜多糖 颗粒剂 成型工艺 |
| 收稿时间： | 2016-03-04 |
Optimum on the forming process of granules of polysaccharides from Dicliptera chinensis (L.) Juss. |
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| XU You-rui,GAO Ya,ZHANG Ke-feng,ZHONG Ming-li,LIN Jia-xun.Optimum on the forming process of granules of polysaccharides from Dicliptera chinensis (L.) Juss.[J].Chinese Journal of Hospital Pharmacy,2016,36(24):2141-2144. |
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| Authors: | XU You-rui GAO Ya ZHANG Ke-feng ZHONG Ming-li LIN Jia-xun |
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| Institution: | College of Pharmacy, Guilin Medical University, Guilin 541004, China |
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| Abstract: | OBJECTIVE To optimize the forming process of granules of polysaccharides from Dicliptera chinensis (L.) Juss. (DCP). METHODS The forming process of granules of DCP was optimized by single factor test and orthogonal test taking the formability, flowablity and dissolubility as the indicators, and the quality of granules of DCP was examined. RESULTS The optimal condition was as follows-DCP-mannitol-3%HPMC aqueous solution=1:2.5:0.035. The granularity, flowablity, dissolubility, moisture and hydroscopicity of obtained granules were all in line with the demand of the Chinese Pharmacopoeia. CONCLUSION The optimal condition is feasible, and can provide basis for the industrialized large-scale production. |
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| Keywords: | polysaccharides of Dicliptera chinensis (L ) Juss granules forming process |
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