抗炎症因子与类风湿性关节炎关系的研究进展

摘要： 类风湿性关节炎 （RA） 是一种慢性炎症性疾病， 疾病晚期可出现关节畸形和功能障碍， 严重危害人类健康。抗炎症因子 （AIC） 作为一种保护性因子， 和促炎症因子 （PIC） 共同在 RA 的发病和进展中发挥重要作用。RA 中 AIC 水平降低， PIC 水平升高， 全身和局部炎症反应加重， 关节软骨和软骨下骨破坏加速， 促进 RA 进一步进展的理念已经被广大学者接受， 以 AIC 为靶点的新一代 RA 生物学治疗方兴未艾。因此深入了解各种 AIC 在 RA 发病中的作用具有重要意义。本文从 AIC 与 RA 的关系和作用机制入手， 对该领域的研究进展进行综述， 为 RA 的临床诊治提供新的思路。

Research progress of the association between anti-inflammatory cytokines and rheumatoid arthritis

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disease. Joint deformity and dysfunction can occur in the late stage of the disease， which is seriously harmful to human health. Anti-inflammatory factors (AIC), as a protective factor, together with pro-inflammatory factors (PIC) play important roles in the pathogenesis and progression of RA. It is widely accepted by the majority of scholars that the decrease of AIC and the increase of PIC in RA can aggravate the systemic and local inflammatory reactions and accelerate the articular cartilage and subchondral bone destruction, resulting in further progress of RA. A new generation of biological therapy for RA targeting at AIC is in the ascendant. Therefore， it is important to understand the role of AIC in the pathogenesis of RA. From the perspective of the relationship between AIC and RA and the mechanism, this article reviews the research progress in this field, which provides new concepts for the diagnosis and treatment of RA.