某院铜绿假单胞菌耐药性与抗菌药物使用量的相关性分析

目的：通过研究铜绿假单胞菌在某医院耐药情况，旨在警示广大医疗工作者提高对细菌耐药性的重视程度，促进临床合理使用抗菌药物。方法：采用回顾性分析方法，调查了某三甲医院2012—2015年抗菌药物的用药频度及铜绿假单胞菌的耐药情况。根据药物流行病学原理，选取铜绿假单胞菌的耐药率变化与抗菌药物用药频度变化为对象，使用SPSS 17.0统计软件进行皮尔森线性回归分析两者之间的相关性，同时采用灰色关联分析法进行相关程度的比较。结果：头孢他啶用药频度与铜绿假单胞菌耐药率呈正相关（r=0.956，P=0.044）。头孢他啶、异帕米星、亚胺培南、左氧氟沙星对铜绿假单胞菌交叉耐药率影响较大。这几种药物使用量增加时，铜绿假单胞菌对其同类药物的耐药率呈上升趋势。结论：抗菌药的使用情况与细菌耐药存在一定的相关性，需加强抗菌药物的使用管理。

Correlation analysis of Pseudomonas aeruginosa resistance and utilization of antibacterial agents in a hospital

OBJECTIVE To provide an evidence of hospital bacterial resistance and promote rational use of antimicrobial drugs through researching resistant Pseudomonas aeruginosa.METHODS Application data from 2012 to 2015 of antimicrobial drugs and resistant Pseudomonas aeruginosa were investigated by retrospective analysis method. According to principles of pharmacoepidemiology, resistant rates of Pseudomonas aeruginosa and defined daily doses were selected as variables. SPSS 17.0 statistical software and grey correlation analysis were applied to compare correlation between them.RESULTS Defined daily doses of ceftazidime and Pseudomonas aeruginosa resistance rates were positively correlated (r=0.956, P=0.049). When defined daily doses of several drugs increased, resistance rates of Pseudomonas aeruginosa to the same drugs would rise. Ceftazidime, isepamicin, imipenem and levofloxacin showed impacts on cross-resistance rate of Pseudomonas aeruginosa.CONCLUSION Certain correlation exists between antibiotic use and bacterial resistance of Pseudomonas aeruginosa, so administration on antibiotics must be enhanced.