2011年郑州市中老年人糖化血红蛋白水平及与代谢综合征及各种代谢紊乱的相关性

目的 探讨中老年社区居民糖化血红蛋白(hemoglobin A1c, HbA1c)水平与代谢综合征(metabolic syndrome, MS)及各种代谢紊乱的相关性。 方法 2011年7月,对郑州市四个社区8 237名社区居民进行问卷调查、体格检查和实验室检查,按照HbA1c＜5.7%,5.7%～,6.5%～分组后调查MS及各种代谢紊乱的患病率,采用Pearson相关分析探讨HbA1c与MS及各项代谢指标的相关性。 结果 中老年社区居民HbA1c水平较高, MS和各种代谢紊乱随着HbA1c水平的升高而升高,当HbA1c≥6.5%时,MS、中心性肥胖、高甘油三酯(high triglyceride,H-TG)血症、低高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)血症的患病率分别为81.7%、78%、50.8%、58%。HbA1c与HDL-C呈负相关;与腰围、体重指数、舒张压、胆固醇、甘油三酯、低密度脂蛋白胆固醇、糖耐量试验2h血糖呈正相关。 结论 2011年郑州市社区中老年人群HbA1c水平较高,HbA1c≥6.5%时MS和各种代谢紊乱的患病率较高,HbA1c与MS和各种代谢紊乱有较强相关性。

Hemoglobin A1c level in the middle-aged and elderly community residents and its correlations with metabolic syndrome and other metabolic disorders in Zhengzhou City, 2011

Objective To investigate hemoglobin A1c (HbA1c) level in the middle-aged and elderly community residents and its correlations with metabolic syndrome (MS) and other metabolic disorders. Methods Questionnaire survey, physical examination and laboratory examination were conducted in 8,237 middle-aged and elderly residents in 4 communities in Zhengzhou City in July, 2011. The prevalence of MS and various metabolic disorders were investigated for groups with HbA1c <5.7%, 5.7%~ and 6.5%~. The correlations of HbA1c with MS and various metabolic disorders were explored by Pearson correlation anlysis. Results The HbA1c level of the middle-aged and elderly residents was high. The prevalence of MS and various metabolic disorders rised with HbA1c level. When HbA1c was 6.5% or higher, the prevalence of MS, central obesity, high triglyceride (H-TG) and low high density lipoprotein cholesterol (HDL-C) was 81.7%, 78.0%, 50.8% and 58.0% respectively. HbA1c was negatively correlated with HDL-C, but positively correlated with waist circumference (WC), body mass index (BMI), diastolic blood pressure (DBP), total cholesterol (TC), TG, low density lipoprotein cholesterol (LDL-C), 2-hour plasma glucose in the oral glucose tolerance test (2hPG) . Conclusions The HbA1c level of the middle-aged and elderly community residents in Zhengzhou City in 2011 is high. When HbA1c is 6.5% or higher, the prevalence of MS and various metabolic disorders increases, and there are strong correlations between HbA1c and MS and various metabolic disorders.