白芍总苷配伍枸杞治疗口腔扁平苔藓患者的疗效评价

目的:评价白芍总苷配伍枸杞治疗口腔扁平苔藓(OLP)患者临床疗效、不良反应及免疫功能的变化。方法:口腔扁平苔藓患者70例随机分为两组,分别为白芍总苷配伍枸杞治疗组和白芍总苷治疗组,观察、比较两组治疗2个月后的临床疗效、免疫功能的变化及用药期间的不良反应。结果:白芍总苷配伍枸杞治疗组总有效率为88.57%,白芍总苷治疗组总有效率为68.57%,白芍总苷配伍枸杞治疗组疗效显著优于白芍总苷组(P<0.05),不良反应轻(P<0.05);同时白芍总苷配伍枸杞治疗组较白芍总苷治疗组OLP患者的补体C3、C4、CD3⁺细胞数升高(P<0.05)。结论:白芍总苷配伍枸杞治疗口腔扁平苔藓患者疗效显著,能较好地调节OLP患者的机体免疫状况,不良反应轻微。

Curative Effect of Total Glucosides of Paeony Combined with Wolfberry in the Treatment of Olp

Objective: To evaluate the clinical efficacy, the adverse reactions and the changes of the immunity state of OLP patients treated with total glucosides of paeony (TGP) combined with wolfberry. Methods: Seventy OLP patients were randomly divided into two groups: one group with oral TGP capsules and Wolfberry; the other group with oral TGP capsules. The clinical efficacy, the adverse reactions and the changes of the immune function were observed after two months. Results: The total effective rate was 88.57% in the combined group, and the total effective rate was 68.57% in the TGP group. The clinical efficacy was better in the combined group with less adverse reaction (P<0.05). However, the numbers of the C3, C4, CD3⁺ cells were increased (P<0.05). Conclusion: Per os TGP combined with Wolfberry showed better therapeutic effect, mild adverse reactions, and might regulate the immunity function of OLP patients.