冠心病合并代谢综合征患者脂联素水平与炎症因子及冠状动脉病变的关系

目的 研究冠心病合并代谢综合征患者脂联素水平与炎症因子水平，并探讨其与冠状动脉病变的关系，为临床治疗提供依据。 方法 选取2013年7月—2015年7月医院收治的冠心病患者190例,根据是否合并代谢综合征将患者分为研究组(n=100)和对照组(n=90),应用全自动生化分析仪检测超敏C反应蛋白(hs-CRP)水平，应用酶联免疫吸附法检测患者血清脂联素水平、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)，比较2组hs-CRP、脂联素水平、TNF-α和IL-6，并比较2组冠脉病变情况。 结果 研究组脂联素水平为(4.78±1.21)mg/L显著低于对照组的(6.59±1.56)mg/L,TNF-α、IL-6以及hs-CRP分别为(25.24±6.28)pg/ml、(132.32±9.24)pg/ml和(6.23±0.29)mg/L均显著高于对照组的(15.53±5.02)pg/ml、(102.91±8.47)pg/ml和(6.23±0.29)mg/L,比较差异具有统计学意义(P＜0.05);研究组冠状动脉三支病变53例显著多于对照组的28例,冠状动脉单支10例显著少于对照组的28例,比较差异具有统计学意义(P＜0.05);Pearson相关性分析显示:脂联素与TNF-α、IL-6、hs-CRP以及冠状动脉病变程度具有负相关关系(P＜0.05)。 结论 冠状动脉合并代谢综合征患者脂联素水平较低,炎症因子较高,冠状动脉病变较重。 

Relationship between adiponectin level and inflammatory factors and coronary artery lesions in patients with coronary heart disease complicated with metabolic syndrome

Objective To study the level of adiponectin and inflammatory factors in patients with coronary heart disease complicated with metabolic syndrome,explore the relationship between them and coronary artery disease,and provide the basis for clinical treatment. Methods Total 190 cases of coronary heart disease in our hospital were selected from July,2013 to July,2015 and divided into study group(100 cases) and control group(n=90 cases) according to the metabolic syndrome.The level of C-reactive protein(hs-CRP) was detected by automatic biochemistry analyzer,and the serum adiponectin level,tumor necrosis factor(TNF-α) and interleukin-6(IL-6) were tested by enzyme-linked immunosorbent assay.The results were compared between the two groups,and their relations with coronary artery disease were analyzed. Results Adiponectin levels in the study group were (4.78±1.21)mg/L which significantly lower than (6.59±1.56)mg/L in the control group;The levels of TNF-α,IL-6 and hs-CRP in the study group were (25.24±6.28)pg/ml,(132.32±9.24)pg/ml and (6.23±0.29)mg/L,respectively,which were significantly higher than (15.53±5.02)pg/ml,(102.91±8.47)pg/ml and (6.23±0.29)mg/L,respectively,in the control group,the difference was statistically significant(P<0.05).There were 53 patients with triple vessels disease in the study group,which were significantly more than 28 cases in the control group;10 patients with single vessels disease,which were significantly less than 28 cases in the control group of 28,the difference was statistically significant(P<0.05);Person correlation analysis showed that the level of adiponectin was negatively correlated with IL-6,hs-CRP,TNF-a and coronary lesions(P<0.05). Conclusion The coronary lesions are more serious in patients with coronary heart disease complicated with metabolic syndrome when the level of adiponectin is lower or the levels of inflammatory factors are higher.