泮托拉唑联合格拉司琼防治化疗所致消化道反应的临床观察

目的观察泮托拉唑与格拉司琼+地塞米松联用治疗肿瘤化疗所致消化道反应的疗效和不良反应。方法将125例化疗所致难治性呕吐的病人随机分为两组,在下一周期化疗中泮托拉唑组予泮托拉唑+格拉司琼+地塞米松,对照组予格拉司琼+地塞米松,比较两组的临床效果与药物不良反应。结果泮托拉唑组在预防食欲不振、抑制恶心、呕吐等方面明显优于对照组,差异有统计学意义(P值均<0.05);两组头晕、腹痛、便秘、乏力、颜面潮红、失眠等不良反应发生率相仿,差异无统计学意义(P值均>0.05)。结论泮托拉唑联合格拉司琼防治化疗药物所致消化道反应疗效较好,值得临床推广应用。

Clinical Study of Pantoprazole Combined with Granisetron on Prevention and Cure of Alimentary Toxicities Caused by Tumor Chemotherapy

Objective 　To investigate the curative and adverse effect s of pantoprazole combined with gran2 iset ron for alimentary toxicities caused by tumor chemotherapy. Methods 　One hundred and twenty2five cases involved in int ractable vomiting caused by tumor chemotherapy were divided into two group s at ran2 dom on the second chemotherapy cycle. Sixty2four patient s of pantoprazole group were t reated with pan2 toprazole + graniset ron + dexathasone ,and sixty2one ones of cont rol group were t reated with graniset ron + dexathasone. Results 　Pantoprazole group was superior to cont rol group in the prevention of appetite loss , nausea and vomiting with significant difference ( P < 0. 05) . Side2effect s such as headache , stomach2 ache , constipation , acratia , blushing , insomnia were similar ( P > 0. 05) . Conclusion 　Pantoprazole com2 bined with graniset ron is a good choice in prevention of alimentary toxicities caused by tumor chemothera2 py and worth extending it s clinical application.