Plasma phosphoglycerate mutase as a marker of muscular dystrophy |
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Authors: | P J Chown E A Barnard P J Barnard P K Liu N D Carter |
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Affiliation: | 1. Department of Biochemistry, Imperial College of Science and Technology, London Great Britain;2. Department of Child Health, St. George''s Hospital Medical School, London Great Britain |
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Abstract: | An elevation of phosphoglycerate mutase (PMG) has been detected in the blood plasma of the genetically dystrophic chicken and in Duchenne muscular dystrophy (DMD) patients. In the dystrophic chicken, plasma PGM in the pectoral muscle was simultaneously depressed to less than one-half that of the normal chicken. In a group of 9 DMD patients, plasma PGM activity was found to be significantly raised above the normal range. A survey of a small group of plasma specimens from human fetuses at risk for muscular dystrophy also suggested that PGM merits investigation as a potential adjunct to other diagnostic indices. |
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Keywords: | Blood enzymes Fetal blood Muscular dystrophy Phosphoglycerate mutase |
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