Underlying undiagnosed inherited marrow failure syndromes among children with cancer |
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| Authors: | Fahad Alabbas Sheila Weitzman Ronald Grant Eric Bouffet David Malkin Oussama Abla Yigal Dror |
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| Institution: | 1. Marrow Failure and Myelodysplasia Program, Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;2. Division of Haematology and Oncology, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada;3. Genetic and Genome Biology Program, The Hospital for Sick Children, Toronto, Ontario, Canada |
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| Abstract: | To study the prevalence of pediatric cancer patients who have underlying inherited bone marrow failure syndrome (IBMFS), we retrospectively reviewed the medical records of newly diagnosed pediatric cancer patients at The Hospital for Sick Children from June 2009 to May 2010, focusing on clinical, laboratory, and treatment‐related findings which may indicate underlying IBMFS. We found five (1.8%) patients out of 276 who had two or more findings suggestive of IBMFS. We conclude that a small fraction of patients with cancer have clinical features that indicate investigations to rule out underlying IBMFSs. A prospective study is needed to determine their prevalence. |
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| Keywords: | bone marrow failure cancer |
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