不同类型钙化在甲状腺结节良恶性诊断中的价值

目的：评价甲状腺结节内不同类型钙化对甲状腺结节良恶性的诊断价值。方法：回顾性分析我院1056例术前行超声检查的甲状腺结节患者的超声资料和临床病理结果，探讨微小钙化、粗大钙化、孤立性钙化、边缘环状钙化和弧形钙化与甲状腺结节良恶性的关系。结果：甲状腺癌结节钙化率为48．4％，良性结节钙化率为17．1％，两组差异有统计学意义（P〈0．001）；微小钙化和粗大钙化在甲状腺癌和良性结节中发生率分别为20．8％、14．1％和3与％、3．2％，两组差异有统计学意义（P〈0．001，P〈0．001）。孤立钙化及环状钙化、弧形钙化在甲状腺良恶性结节中的发生率差异无统计学意义（P〉0．05）。微小钙化是甲状腺癌结节伴钙化最主要的形式（43．3％），粗大钙化位居第二；在良性结节中，不同钙化类型各项比例分布相似。结论：钙化尤其是微小钙化和粗大钙化，对甲状腺癌的诊断具有重要意义。

Diagnosis value of various patterns of calcifcation in benign and malignant thyroid nodules

Obejective： To investigate the diagnosis value of various patterns of calcifcation in benign and malignant thyroid nodules. Methods： We retrospectively reviewed the clinical pathology data and ultrasonographic characteristics of 1 056 thyroid nodules who received preoperative ultrasound examinations and subsequently underwent thyroidectomy in Provincial Hospital Affiliated to Shandong University in China and explored the relationship between microcalcifcation, annular-like peripheral calcifcation, crescent-like peripheral calcifcation, intranodular coarse calcifcation, and calcifed spot with thyroid carcinoma. Results.. Calcifcations were detected in 48.4% of malignant nodules and 17.1% of benign nodules. The incidences of calcification were significantly higher in malignant group than in benign group（P〈0.001 ）. The incidences of microcalcifcation and intranodular in malignant group and benign group were 20.8%, 14.1% and 3.5%, 3.2%, there are a signifcant difference in malignant group and benign group （P〈0.001）. The incidences of annular-like peripheral calcifcation, crescent-like peripheral calcification and calcifed spot had no significant difference in malignant group and benign group（P〉0.05）. Of the malignant nodules with calcifcation, microcalcif- cation was the most common pattern, occurring in 43.3% and intranodular type was the second common pattern, occurring in 29.1%. Of the benign nodules with calcifcation, each calcifcation type were distributed into similar portion. Conclusion： Calcification, especially microcalcifcation and intranodular calcifcation have signifant diagnosis value in thyroid carcinooma.