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| Merkel细胞癌的临床影像特征及病理基础(附典型病例) | |
| 引用本文： | 张书田,张丹,李美芳,邢传平.Merkel细胞癌的临床影像特征及病理基础(附典型病例)[J].医学综述,2010,16(12). |
| 作者姓名： | 张书田 张丹 李美芳 邢传平 |
| 作者单位： | 1. 中国人民解放军白求恩国际和平医院放射科,石家庄,050082 2. 重庆医科大学医学检验系,重庆,401331 3. 石家庄市第四医院检验科,石家庄,050014 4. 中国人民解放军兰州军区总医院病理科,兰州,730050 |
| 摘 要： | 目的总结Merkel细胞癌的临床影像及病理特征。方法对64例Merkel细胞癌患者的临床病史、影像表现、肿瘤组织的病理形态和免疫组化表达进行回顾性分析。结果肿瘤常见于头颈部及四肢,易局部复发并转移。病理特点为电镜下瘤细胞胞质内含大量带膜神经内分泌颗粒,角蛋白、神经烯醇化酶、嗜铬素和突触素阳性。CT和MRI上可见异常增强的占位病变,边界清晰。本病预后较差。结论 Merkel细胞癌临床上罕见,主要靠病理诊断。 |
| 关 键 词： | Merkel细胞癌 神经内分泌癌 皮肤肿瘤 CT 碰共振成像 影像诊断学 病理学 |
The Clinical and Imaging Feature of Merkel Cell Carcinoma and Its Pathologic Basis(Analysis of Cases) |
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| Abstract: | Objective To study the clinicopathology and imaging features of Merkel cell carcinoma.Methods With review of the clinical history,imaging feature,histopathological changes and immunohistochemical expression were investigated in 64 cases of Merkel cell carcinoma.Results The head and neck are the most common site for this carcinoma.It has an obvious tendency of local recurrence and metastasis.There were numerous membrane bounded electron-dense neuroendocrine granules in the cytoplasm of Merkel cell carcinoma.Cytokeratin,neurospecific enolase,chromogranin A and synaptosin were positive in most cells.The tumors border were clear in enhanced CT and MRI.The prognose is poor.Conclusion It is rare in clinical practice.The diagnosis is mainly made on pathology. |
| Keywords: | CT |
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