| 大豆多肽的毒性研究 |
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| 引用本文： | 郭婕,王爱华,程东,颜燕,杨非.大豆多肽的毒性研究[J].齐鲁药事,2008,27(11). |
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| 作者姓名： | 郭婕 王爱华 程东 颜燕 杨非 |
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| 作者单位： | 1. 山东省疾病预防控制中心,山东,济南,250014
2. 山东中医药大学第二附属医院,山东,济南,250013 |
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| 摘 要： | 目的研究大豆多肽的毒性。方法小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、大鼠30d喂养试验。结果Ames试验、微核试验和精子畸形试验结果均为阴性;大鼠30d喂养试验结果显示该样品30d喂养对大鼠各项观察指标未见毒性作用。结论在本次实验条件下,大豆多肽为无毒物质,未显示有遗传毒性和亚急性毒性作用。
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| 关 键 词： | 大豆多肽 急性毒性试验 遗传毒性试验 大鼠30天喂养试验 |
Study on toxicity of soy peptide |
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| GUO Jie,WANG Ai-hua,CHENG Dong,YAN Yan,YANG Fei.Study on toxicity of soy peptide[J].qilu pharmaceutical affairs,2008,27(11). |
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| Authors: | GUO Jie WANG Ai-hua CHENG Dong YAN Yan YANG Fei |
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| Institution: | GUO Jie,WANG Ai-hua1,CHENG Dong,YAN Yan,YANG Fei |
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| Abstract: | OBJECTIVE To study toxicity of Soy Peptide.METHODS Acute toxicity testing of mice,Ames test,mictronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice,thirty days feeding study.RESULTS The results of genetic toxicity test were all negative,including Ames test,micronucleus test and sperm shape abnormality test.The results of thirty days feeding study was also negative.CONCLUSION Soy Peptide is a substance with no acute toxicity and has no genetic toxicity and subacute toxicity in this test. |
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| Keywords: | Soy Peptide acute toxicity testing genetic toxicity thirty days feedings study |
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