| Electrophysiological and Inotropic Effects of Iodium-Heterocyclic Compound on lsolated Guinea Pig Papillary Muscles |
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| 引用本文： | 曹维,赵德化,盛宝恒. Electrophysiological and Inotropic Effects of Iodium-Heterocyclic Compound on lsolated Guinea Pig Papillary Muscles[J]. 中国人民解放军军医大学学报, 1989, 0(2) |
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| 作者姓名： | 曹维 赵德化 盛宝恒 |
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| 作者单位： | Department of Pharmacology Fourth Military Medical University，Xi'an，Department of Pharmacology，Fourth Military Medical University，Xi'an，Department of Pharmacology，Fourth Military Medical University，Xi'an |
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| 摘 要： | The effects of iodium-heterocyclic compound(3,6-di-[dimethytamino]-dibcnzopyrodoniun formate,IHC-64)on the action potentials and contractile force of the isolatedguinca pig papillary muscles were investigatad.50 μmol/L IHC-64 only inhibited contractile forceand had no effect on APA,dv/dt max,APD_50 and APD_90 of fast action potentials in Tyrode's so-lution.All of these parametres were depressed by further increasing concentration of IHC-64.InK-rich Tyrodc's solution,the depressive action of IHC-64 on slow action potentials andcontractile force could be antagonized by incrcased extracellular calcium.These results suggesr thatIHC-64 inhibit not only slow calcium influx but also fast sodium influx,and it may.(?)new calci-urn channd blockcr.
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Electrophysiological and Inotropic Effects of Iodium-Heterocyclic Compound on lsolated Guinea Pig Papillary Muscles |
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| Cao wei Zhao Dehua Sheng Baoheng. Electrophysiological and Inotropic Effects of Iodium-Heterocyclic Compound on lsolated Guinea Pig Papillary Muscles[J]. Journal of Medical Colleges of PLA(China), 1989, 0(2) |
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| Authors: | Cao wei Zhao Dehua Sheng Baoheng |
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| Affiliation: | Cao wei Zhao Dehua Sheng Baoheng Department of Pharmacology,Fourth Military Medical University,Xi'an |
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| Abstract: | |
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| Keywords: | iodium-heterocyclic compound calcium channel blocker papillary muscle action polential contractile force of myocardium |
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