Isolated hepatic perfusion chemotherapy for unresectable malignant hepatic tumors |
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Authors: | Ku Yonson Tominaga Masahiro Iwasaki Takeshi Fukumoto Takumi Kuroda Yoshikazu |
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Institution: | (1) Department of Gastroenterological Surgery, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan Tel. +81-78-382-5921; Fax +81-78-382-5939 e-mail: yonson@med.kobe-u.ac.jp, JP |
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Abstract: | Treatment failure with conventional approaches, including systemic and regional chemotherapy, for refractory advanced primary
or metastatic hepatic cancers has evoked periodic waves of enthusiasm for isolated hepatic perfusion (IHP) over the past 50
years. With technical refinements of the procedure and the introduction of a novel biochemical regimen combining tumor necrosis
factor and melphalan, several hepatobiliary-oncological centers initiated clinical trials of IHP in the 1990s. In parallel,
a percutaneous technique of IHP has been developed in this era as a minimally invasive, simple form of IHP, and phase I and
II studies have been done in some specialized centers. This study attempts to review past and current techniques of IHP, and
to outline their possible role in the treatment of unresectable hepatic tumors, with special reference to hepatocellular carcinoma
and colorectal hepatic metastases.
Received: January 10, 2002 |
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Keywords: | Isolated hepatic perfusion High-dose chemotherapy Hepatocellular carcinoma Colorectal hepatic metastasis Hepatic arterial infusion |
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