宫腔灌注顺铂治疗功能失调性子宫出血10例

目的：探索宫腔灌注顺铂功能失调性子宫出血（功血）的疗效。方法：选１０例无生育要求的功血患者,将１０ｍｇ顺铂稀释至１０ｍＬ,每次注入宫腔６ｍｌ￣８ｍＬ,４次为一疗。结果：１０例患者中６例既往月经过多者治疗后月经量明显减少;４例经期延长者治疗后经期变为突兀蝮查宫内膜病理变化,其中４例子宫内膜单纯增生生长,１例囊腺样增生及１例腺生者,治疗一个疗程后的转变为分泌期内膜,结论：宫膜腔注顺铂可逆转宫内膜病理变

Uterine infusion of cisplatin in treating 10 patients with dysfunctional uterine bleeding

AIM: To explore the uterine infusion of cisplatin in treating dysfunctional uterine bleeding. METHODS: Ten cases with dysfunctional uterine bleeding and no further desire for pregnancy were selected. 10 mg cisplatin was diluted to 10 mL and 6 to 8 mL was infused into the uterine of every case once a week. Four times made up one course of treatment. RESULTS: After treatment, 6 from the 10 cases with menorrhagia displayed significantly diminished menstrual flow. Menstruation of the other 4 cases with previous lengthened menstrual bleeding became normal. Endometrium of 6 cases with endometrial hyperplasia ( n =4), cystic glandular hyperplasia ( n =1) and adenomatous hyperplasia ( n =1) was transformed as secretive phase of endometrium after one course of treatment. CONCLUSION: Uterine infusion of cisplatin can transform inversely histological change of endometrium, decrease menstrual flow as well as shorten the bleeding duration, which can be applied in the treatment of dysfunctional uterine bleeding.