类风湿关节炎与TLR4单核苷酸多态性关联研究的Meta分析

目的探讨类风湿关节炎(RA)与TLR4基因Asp299Gly多态性的关联情况。方法检索已发表的有关RA和TLR4基因Asp299Gly多态性的文献．进行Meta分析。结果3项研究共纳入718例RA患者和1392名正常对照，综合分析显示TLR4基因Asp299Gly多态性不是RA的关联基因，OR=1．23(0．67，2．25)，P=0．5；TLR4基因Asp299Gly多态性分布在男女性RA患者分布差异无统计学意义，OR=0．48(0．22．1．03)，P=0．06：在共同表位基因阳性和阴性患者组差异无统计学意义，OR=0．67(0．40，1．13)，P=0．13；在类风湿因子(RF)阳性和阴性患者组差异无统计学意义，OR=I．02(0．51，2．02)，P=-I；RA患者中，Asp299Asp基因型患者发病早于Asp299Gly基因型者，OR=-4．35(-7．45，-1．25)，P=0．006。结论Meta分析显示，TLR4基因Asp299Gly多态性与RA易感性无关联．但Asp299Asp基因型者起病早于Asp299Gly基因型者。应在东方人群进一步开展随机对照和前瞻的队列研究揭示其在RA发病中的作用。

The association between rheumatoid arthritis with TLR4 Asp299Gly functional variant: the meta-analysis

Objective To explore the association between rheumatoid arthritis (RA) with TLR4 Asp299Gly functional variant. Method The literature about RA and TLR4 Asp299Gly functional variant were searched and the meta-analysis was performed. Results Three studies enrolled 718 RA patients and 1392 controls in total. The analysis showed that the TLR4 Asp299Gly functional variant was neither associated with the susceptibility of RA OR=1.23 (0.67, 2.25), P=0.5]; nor associated with SE or RF OR=0.67 and 1.02 respectively]; while the TLR4 Asp299Gly functional variant was associated with the age of onset OR=-4.35 (-7.45, -1.25), P=0.006]. Conclusion The meta-analysis reveals that the TLR4 Asp299Gly functional variant is not associated with the susceptibility of RA, but the onset of RA is earlier in the AA type than those in the AG type. Further prospective corhort studies should be carreied out in the future, especially in oriential people.