| 趋化素样因子2 mRNA在心肌肥厚大鼠心肌中的表达 |
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| 引用本文： | 任鸿坤,洪涛,蒋捷,龚艳君,王志坚,卜定方,周爱儒. 趋化素样因子2 mRNA在心肌肥厚大鼠心肌中的表达[J]. 北京大学学报(医学版), 2004, 36(4): 399-402 |
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| 作者姓名： | 任鸿坤 洪涛 蒋捷 龚艳君 王志坚 卜定方 周爱儒 |
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| 作者单位： | 北京大学第一医院心内科,北京,100034;北京大学第一医院中心实验室,北京,100034;北京大学基础医学院 |
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| 基金项目： | 面向21世纪教育振兴行动计划(985计划) |
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| 摘 要： | 目的:检测趋化素样因子2(chemokine-like factor 2,CKLF2)mRNA在心肌肥厚大鼠心肌中的表达.方法:实验组以手术缩窄大鼠腹主动脉致心肌肥厚,对照为假手术组;应用竞争PCR方法检测两组左心室CKLF2mRNA表达差异.结果:与假手术组相比,手术组术后早期(第17天)心肌中CKLF2mRNA表达增高,第45天时降到假手术组水平.结论:CKLF2mRNA在心肌肥厚早期表达增加.
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| 关 键 词： | 趋化因子 心肌病 肥大性 聚合酶链反应 |
| 文章编号： | 1671-167X(2004)04-0399-04 |
| 修稿时间： | 2004-02-19 |
Expression of chemokine-like factor 2 (CKLF2) mRNA in rat myocardium with hypertrophy |
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| Hong-kun Ren,Tao Hong,Jie Jiang,Yan-jun Gong,Zhi-jian Wang,Ding-fang Bu,Ai-ru Zhou. Expression of chemokine-like factor 2 (CKLF2) mRNA in rat myocardium with hypertrophy[J]. Journal of Peking University. Health sciences, 2004, 36(4): 399-402 |
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| Authors: | Hong-kun Ren Tao Hong Jie Jiang Yan-jun Gong Zhi-jian Wang Ding-fang Bu Ai-ru Zhou |
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| Affiliation: | Department of cardiology, Peking University First Hospital, Beijing 100034,China. |
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| Abstract: | Objective: To investigate the expression of CKLF2 mRNA in the rat myocardium with hypertrophy. Methods: Rat abdominal aorta was constricted by operation to make myocardium hypertrophy in the hypertrophy gronp and the control group was subjected to the sham operation. The CKLF2 mRNA expressions were tested by competitive polymerase chain reaction (CPCR). Results: Compared to the control group, the expression of CKLF2 mRNA of hypertrophy group significantly increased on the 17th day after operation, and decreased to the control level on the 45th day. Conclusion: The expression of rCKLF2 mRNA in rat myocardium with hypertrophy significantly increased in early days of hypertrophy. |
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| Keywords: | Chemotactic factors Cardiomyopathy hypertropic Polymerase chain reaction |
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