| 磁性明胶微球体内分布实验研究 |
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| 引用本文： | 吴传斌,赵延乐,何素梅,魏树礼. 磁性明胶微球体内分布实验研究[J]. 药学学报, 1993, 28(6): 464-468 |
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| 作者姓名： | 吴传斌 赵延乐 何素梅 魏树礼 |
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| 作者单位： | 北京医科大学药学院，北京医科大学药学院，北京医科大学药学院，北京医科大学药学院 北京 100083 军事医学科学院毒物药物研究所 100850，北京 100083，北京 100083，北京 100083 |
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| 基金项目： | 国家医药管理局“八五”国家科技攻关专题,编号85—922—03—08 |
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| 摘 要： | 对磁性明胶微球进行了同位素标记。用γ-闪烁照相技术观察了磁性明胶微球在兔体内的分布。结果表明:靶部位的放射活性加磁场是未加磁场的15倍,而且施加磁场时间长和磁场强度大有利于磁性明胶微球定位于靶区。文中也介绍了自行设计的外加磁场装置。
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| 关 键 词： | 磁场 明胶 微球 锝 过锝酸盐 |
| 收稿时间： | 1992-10-26 |
STUDIES ON DISTRIBUTION OF MAGNETIC GELATIN MICROSPHERES IN RABBITS |
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| CB Wu,YL Zhao,SM He and SL Wei. STUDIES ON DISTRIBUTION OF MAGNETIC GELATIN MICROSPHERES IN RABBITS[J]. Acta pharmaceutica Sinica, 1993, 28(6): 464-468 |
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| Authors: | CB Wu YL Zhao SM He SL Wei |
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| Abstract: | In this report, the technique of labelling MG-ms with ~(99m)Tc as pertechnetate in the presence of a reducing agent such as SnCl_2 was described. The distribution of intravenously injected ~(99m)Tc-labelled MG-ms in rabbits at different intervals of magnetic field applied and different magnetic field intensity was investigated by using an externally applied magnetic field and measuring the radioactivity at the rabbit head and other organs. When magnet was used, the radioactivity in the head, target site, was 15 times more than that when magnet was not used. At the same time, the radioactivity of the lung was 5 times less than that when magnet was not used. The newly designed magnetic field equipment was presented. |
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| Keywords: | Magnetic field Gelatin Microspheres Technetium Pertechnetate |
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