| P53、Fas、Bcl-2基因在尖锐湿疣和宫颈癌组织中的表达 |
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| 引用本文： | 夏克栋,林巧爱,董海艳,张丽芳,胡芸,董缪武.P53、Fas、Bcl-2基因在尖锐湿疣和宫颈癌组织中的表达[J].温州医学院学报,2004,34(2):82-84. |
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| 作者姓名： | 夏克栋 林巧爱 董海艳 张丽芳 胡芸 董缪武 |
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| 作者单位： | 1. 温州医学院,微生物学免疫学教研室,浙江,温州,325027
2. 温州医学院,病理学教研室,浙江,温州,325027 |
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| 基金项目： | 浙江省温州市科技局资助项目 |
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| 摘 要： | 目的:探讨P53、Fas、Bcl-2基因蛋白表达与尖锐湿疣和宫颈癌发病的关系.方法:采用标准免疫组化技术,分别检测24例尖锐湿疣、46例宫颈癌、22例宫颈糜烂和28例正常宫颈组织P53、Fas和Bcl-2基因产物.结果:三种基因蛋白在尖锐湿疣组和宫颈癌组的表达程度和表达率均显著高于宫颈糜烂组和正常对照组(P＜0.001).尖锐湿疣组和宫颈癌组之间在P53的表达程度上差异有显著性(P＜0.05).结论:P53、Fas、Bcl-2基因表达与尖锐湿疣和宫颈癌的发病均有密切关系.
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| 关 键 词： | 尖锐湿疣 宫颈癌 |
| 文章编号： | 1000-2138(2004)02-0082-03 |
| 修稿时间： | 2003年8月28日 |
Expression of P53, Fas and Bcl-2 in condyloma acuminatum and cervical cancer |
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| XIA Ke-dong,LIN Qiao-ai,DONG Hai-yan,et al..Expression of P53, Fas and Bcl-2 in condyloma acuminatum and cervical cancer[J].Journal of Wenzhou Medical College,2004,34(2):82-84. |
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| Authors: | XIA Ke-dong LIN Qiao-ai DONG Hai-yan |
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| Institution: | XIA Ke-dong,LIN Qiao-ai,DONG Hai-yan,et al.Department of Microbiology and Immunology,Wenzhou Medical College,Wenzhou 325027 |
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| Abstract: | Objective:To explore the pathogenetic relationship between expressions of P53, Fas and Bcl-2 associated with condyloma acuminatum(CA) and cervical cancer.Methods:The expressions of P53,Fas and Bcl-2 were detected using immuohistochemical technique in 24 specimens of CA,46 specimens of cervical cancer,22 specimens of cervicitis and 28 specimens of normal cervical tissue.Results:The expressive degree and expressive rate of p53,Fas and Bcl-2 in CA and cervical cancer were significantly higher than that in cervicitis and normal cervical tissue(p<0.001). The expressive degree of p53 was significantly difference between CA and cervical cancer(P<0.05).Conclusion:The expressions of p53,Fas and Bcl-2 were significantly correlated with the occurrences of both condyloma acuminatum and cervical cancer. |
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| Keywords: | P53 Fas Bcl-2 |
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