| Effects of Phentolamine on Hemorrheology and Hemodynamics in Dogs with Acute Liver Damage |
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| 引用本文： | 但自力,张文英,李绍白. Effects of Phentolamine on Hemorrheology and Hemodynamics in Dogs with Acute Liver Damage[J]. 华中科技大学学报(医学英德文版), 1996, 16(3): 164-167. DOI: 10.1007/BF02908799 |
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| 作者姓名： | 但自力 张文英 李绍白 |
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| 作者单位： | Institute of Liver Diseases，Tongji Medical University，Wuhan 430030 |
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| 摘 要： | ＥｆｆｅｃｔｓｏｆＰｈｅｎｔｏｌａｍｉｎｅｏｎＨｅｍｏｒｒｈｅｏｌｏｇｙａｎｄＨｅｍｏｄｙｎａｍｉｃｓｉｎＤｏｇｓｗｉｔｈＡｃｕｔｅＬｉｖｅｒＤａｍａｇｅＤＡＮＺｉｌｉ（但自力）；ＺＨＡＮＧＷｅｎｙｉｎｇ（张文英）；ＬＩＳｈａｏｂａｉ（李绍白）（Ｉｎ...
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Effects of phentolamine on hemorrheology and hemodynamics in dogs with acute liver damage |
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| Dan Zili,Zhang Wenying,Li Shaobai. Effects of phentolamine on hemorrheology and hemodynamics in dogs with acute liver damage[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1996, 16(3): 164-167. DOI: 10.1007/BF02908799 |
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| Authors: | Dan Zili Zhang Wenying Li Shaobai |
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| Affiliation: | 1. Institute of Liver Diseases, Tongji Medical University, 430030, Wuhan
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| Abstract: | The effects of phentolamine on hemorrheology and hemodynamics were studied in dogs with acute liver damage induced by acetaminophen. After 1 h of phentolamine application , the viscosity of plasma and whole blood was significantly diminished. The hematocrit readings followed the same pattern as the alterations in viscosity. The portal venous resistance and the value of K were remarkably decreased and the portal venous blood flow was obviously increased. It can be assumed , therefore , that the decrease in viscosity induced by phentolamine results from internal hemodilution and phentolamine may improve hepatic blood circulation through the decrease of portal venous resistance caused by the reduction of blood viscosity and the dilation of portal vascular beds. |
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| Keywords: | phentolamine blood viscosity hemdynamics acute liver damage liver circulation hemodilution |
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