^99Tc^m-HL91显像监测高压氧前后小鼠肿瘤乏氧状态的改变

目的探讨^99Tc^m-HL91乏氧显像在高压氧治疗前后监测肿瘤乏氧状态的可行性。方珐将10只荷H。肝癌KM小鼠在高压氧（Hyperbaric oxygen，HBO）治疗前后分别进行^99Tc^m-HL91乏氧显像，对图像进行肉眼观察及T/NT值（肿瘤与非肿瘤）比较。结果肿瘤组织对放射性核素的摄取较治疗前明显减少，T/NT值也明显减低，可见显著性差异（P〈0．05）。结论HBO治疗后荷H22肝癌小鼠肿瘤部位的乏氧组织明显减少，^99Tc^m-HL91乏氧显像是一种无创监测肿瘤组织乏氧状态的有效方法。

Experimental research on detecting hypoxic status of tumors pre and after HBO with 99Tcm-HL91 image in mice

Objective To evaluate the hypoxia status of tumor pre and after HBO with ^99Tc^m-HL91 hypoxic image. Methods ^99Tc^m-HL91 hypoxia images were taken separately pre and after HBO （Hyperbaric oxygen,HBO） in 10 mices bearing H22 liver cancer cell,all images were analysed with ratios of T （tumor）/NT （contralateral re-gion）. Results The uptake of the radionuclide in tumor tissue significantly reduced than that pre HBO treatment,and the ratios of T/NT decreased than that pre HBO,there were significant differences （P〈0.05）. Conclusion The hypoxia tissue in tumors of mices ^99Tc^m-HL91 hypoxia images bearing H22 liver cancer cell were reduced significantly after HBO treatment,and the may be avery effective way in monitoring hypoxic status of tumor.